Detection and isolation of circulating tumor cells in urologic cancers: A review

被引：51

作者：

Loberg, RD

Fridman, Y

Pienta, BA

Keller, ET

McCauley, LK

Taichman, RS

Pienta, KJ

机构：

[1] Univ Michigan, Ctr Comprehens Canc, Dept Urol, Urol Ctr, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA

[3] Univ Michigan, Sch Med, Unit Lab Anim Med, Ann Arbor, MI USA

[4] Univ Michigan, Sch Dent, Dept Periodont Prevent Geriat, Ann Arbor, MI USA

[5] Univ Michigan, Sch Dent, Ctr Biorestorat Oral Hlth, Ann Arbor, MI USA

[6] Univ Michigan, Ctr Comprehens Canc, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

来源：

NEOPLASIA | 2004年 / 6卷 / 04期

关键词：

cancer; circulating tumor cells; prostate; renal; bladder;

D O I：

10.1593/neo.03484

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The American Cancer Society has estimated that in 2003, there will be approximately 239,600 new cases of urologic cancer diagnosed and 54,600 urologic cancer-related deaths in the United States. To date, the majority of research and therapy design have focused on the microenvironment of the primary tumor site, as well as the microenvironment of the metastatic or secondary (target) tumor site. Little attention has been placed on the interactions of the circulating tumor cells and the microenvironment of the circulation (i.e., the third microenvironment). The purpose of this review is to present the methods for the detection and isolation of circulating tumor cells and to discuss the importance of circulating tumor cells in the biology and treatment of urologic cancers.

引用

页码：302 / 309

页数：8

共 71 条

[31]

Hara N, 2002, CLIN CANCER RES, V8, P1794

[32] Frequency of PSA-mRNA-bearing cells in the peripheral blood of patients after prostate biopsy [J].