Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice... or Didn't!

被引：4

作者：

Zakeri, Kaveh ^{[1
,2
]}

Coleman, C. Norman ^{[1
]}

Vikram, Bhadrasain ^{[1
]}

机构：

[1] NCI, Radiat Res Program, Div Canc Treatment & Diag, Rockville, MD 20850 USA

[2] Univ Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA

来源：

FRONTIERS IN ONCOLOGY | 2018年 / 8卷

关键词：

randomized trials; radiation oncology; survival; local control; adverse events; CELL LUNG-CANCER; EARLY BREAST-CANCER; PROPHYLACTIC CRANIAL IRRADIATION; RATE BRACHYTHERAPY BOOST; EXTERNAL-BEAM BOOST; OPEN-LABEL; RADIOTHERAPY HYPOFRACTIONATION; UK STANDARDIZATION; INTRAOPERATIVE RADIOTHERAPY; ADVANCED TECHNOLOGIES;

D O I：

10.3389/fonc.2018.00130

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a two-part article published in 2009, we discussed the limitations of conventional radiation therapy, the challenges of studying new technologies in radiation oncology, and summarized the state-of-the science for various malignancies (1, 2). Here, we summarize some of the most important prospective, randomized trials that during the intervening years have attempted to improve the tumor control and/or decrease the adverse effects of radiation therapy. For consistency, we have focused here on the null and alternate hypotheses as articulated by the investigators at the onset of each trial, since the outcome of the investigational treatment should be considered clinically significant only if the null hypothesis was rejected. The readers (and patients) are of course free to make their own judgments about the clinical significance of the results when the null hypothesis was not rejected.

引用

页数：10

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