Back to Basics: Exploiting the Innate Physico-chemical Characteristics of Nanomaterials for Biomedical Applications

被引：201

作者：

Tay, Chor Yong ^{[1
]}

Setyawati, Magdiel Inggrid ^{[1
]}

Xie, Jianping ^{[1
]}

Parak, Wolfgang J. ^{[3
,4
]}

Leong, David Tai ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore

[2] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 117456, Singapore

[3] Univ Marburg, Fachbereich Phys, D-35032 Marburg, Germany

[4] CIC Biomagune, Donostia San Sebastian 20009, Gipuzkoa, Spain

来源：

ADVANCED FUNCTIONAL MATERIALS | 2014年 / 24卷 / 38期

关键词：

nanobiology; nanoparticles; nanomaterials; nanomedicine; nanotechnology; biomedicine; WALLED CARBON NANOTUBES; MESOPOROUS SILICA NANOPARTICLES; TITANIUM-DIOXIDE NANOPARTICLES; EPITHELIAL-MESENCHYMAL TRANSITION; SUPERPARAMAGNETIC IRON-OXIDE; PROTEIN CORONA COMPOSITION; ATOMIC-FORCE MICROSCOPY; HUMAN-SERUM-ALBUMIN; GOLD-NANOPARTICLES; IN-VITRO;

D O I：

10.1002/adfm.201401664

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In nanomedicine design, emphasis is centered on the engineered impacts of the nanomaterials (NMs). However, failure to understand the unintended effects of nanomaterials on the cell biology can affect the overall performance, approval, and adoption in the clinic. Much of these unintended effects arise from unique physico-chemical properties of the NMs. This feature article discusses some of the key physico-chemical parameters of NMs and highlights how they could cause unexpected and novel biological responses, with some insights into their underlying mechanisms.

引用

页码：5936 / 5955

页数：20

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