Apoptotic Death of Cancer Stem Cells for Cancer Therapy

被引：45

作者：

He, Ying-Chun ^{[1
]}

Zhou, Fang-Liang ^{[1
]}

Shen, Yi ^{[2
]}

Liao, Duan-Fang ^{[1
]}

Cao, Deliang ^{[1
,2
]}

机构：

[1] Hunan Univ Tradit Chinese Med, Coll Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China

[2] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62702 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 05期

基金：

中国国家自然科学基金;

关键词：

cancer stem cells; side population; apoptosis; apoptotic inducers; apoptotic death pathways; cancer therapy; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; UP-REGULATION; KAPPA-B; HEPATOCELLULAR-CARCINOMA; STEM/PROGENITOR CELLS; MAMMOSPHERE FORMATION; INDUCE APOPTOSIS; SIDE-POPULATION; GENE-EXPRESSION;

D O I：

10.3390/ijms15058335

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective CSC apoptotic inducers are introduced and their therapeutic potentials are discussed. These include synthetic and natural compounds, antibodies and recombinant proteins, and oligonucleotides.

引用

页码：8335 / 8351

页数：17

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