Genetics and genomics of SARS-CoV-2: A review of the literature with the special focus on genetic diversity and SARS-CoV-2 genome detection

被引：117

作者：

Rahimi, Azadeh ^{[1
]}

Mirzazadeh, Azin ^{[2
,3
,4
]}

Tavakolpour, Soheil ^{[5
]}

机构：

[1] Isfahan Univ Med Sci, Fac Med, Dept Genet & Mol Biol, Esfahan, Iran

[2] Shahid Sadoughi Univ Med Sci, Fac Med, Dept Med Genet, Yazd, Iran

[3] Univ Arkansas, Joint Bioinformat Grad Program, Little Rock, AR 72204 USA

[4] Univ Arkansas Med Sci, Little Rock, AR 72205 USA

[5] Harvard Med Sch, Dana Farber Canc Inst, Boston, MA 02215 USA

来源：

GENOMICS | 2021年 / 113卷 / 01期

关键词：

Coronavirus; SARS-CoV-2; COVID-19; Genetics; Vaccine; Treatment; Molecular diagnosis; REAL-TIME PCR; SARS CORONAVIRUS; RNA INTERFERENCE; AMPLIFICATION ASSAY; VIRUS; SIRNA; EXPRESSION; REPLICATION; INHIBITION; MUTATIONS;

D O I：

10.1016/j.ygeno.2020.09.059

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The outbreak of 2019-novel coronavirus disease (COVID-19), caused by SARS-CoV-2, started in late 2019; in a short time, it has spread rapidly all over the world. Although some possible antiviral and anti-inflammatory medications are available, thousands of people are dying daily. Well-understanding of the SARS-CoV-2 genome is not only essential for the development of new treatments/vaccines, but it also can be used for improving the sensitivity and specificity of current approaches for virus detection. Accordingly, we reviewed the most critical findings related to the genetics of the SARS-CoV-2, with a specific focus on genetic diversity and reported mutations, molecular-based diagnosis assays, using interfering RNA technology for the treatment of patients, and genetic-related vaccination strategies. Additionally, considering the unanswered questions or uncertainties in these regards, different topics were discussed.

引用

页码：1221 / 1232

页数：12

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