Gravimetric Viral Diagnostics: QCM Based Biosensors for Early Detection of Viruses

被引:104
作者
Afzal, Adeel [1 ,2 ]
Mujahid, Adnan [3 ]
Schirhagl, Romana [4 ]
Bajwa, Sadia Zafar [5 ]
Latif, Usman [2 ]
Feroz, Saima [6 ,7 ]
机构
[1] Univ Hafr Al Batin, Coll Sci, Dept Chem, POB 1803, Hafar al Batin 31991, Saudi Arabia
[2] COMSATS Inst Informat Technol, Interdisciplinary Res Ctr Biomed Mat, 1-5 KM Def Rd,Raiwind Rd, Lahore 54000, Pakistan
[3] Univ Punjab, Inst Chem, Quaid I Azam Campus, Lahore 54590, Pakistan
[4] Univ Groningen, Univ Med Ctr Groningen, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands
[5] NIBGE, Faisalabad 38000, Pakistan
[6] COMSATS Inst Informat Technol, Dept Biosci, Pk Rd, Islamabad 45550, Pakistan
[7] Univ Hafr Al Batin, Coll Sci, Dept Biol, Female Campus, Hafar al Batin 31991, Saudi Arabia
关键词
antibodies; aptamer; epitope imprinting; molecularly imprinted polymers; quartz crystal microbalance; virus sensor; QUARTZ-CRYSTAL MICROBALANCE; MOLECULARLY IMPRINTED POLYMERS; HEPATITIS-B-VIRUS; SURFACE-PLASMON RESONANCE; SELF-ASSEMBLED MONOLAYERS; SENSITIVE DETECTION; DNA APTAMERS; RAPID DETECTION; PIEZOELECTRIC BIOSENSORS; SOFT LITHOGRAPHY;
D O I
10.3390/chemosensors5010007
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Viruses are pathogenic microorganisms that can inhabit and replicate in human bodies causing a number of widespread infectious diseases such as influenza, gastroenteritis, hepatitis, meningitis, pneumonia, acquired immune deficiency syndrome (AIDS) etc. A majority of these viral diseases are contagious and can spread from infected to healthy human beings. The most important step in the treatment of these contagious diseases and to prevent their unwanted spread is to timely detect the disease-causing viruses. Gravimetric viral diagnostics based on quartz crystal microbalance (QCM) transducers and natural or synthetic receptors are miniaturized sensing platforms that can selectively recognize and quantify harmful virus species. Herein, a review of the label-free QCM virus sensors for clinical diagnostics and point of care (POC) applications is presented with major emphasis on the nature and performance of different receptors ranging from the natural or synthetic antibodies to selective macromolecular materials such as DNA and aptamers. A performance comparison of different receptors is provided and their limitations are discussed.
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页数:25
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