Extracellular vesicles in type 2 diabetes mellitus: key roles in pathogenesis, complications, and therapy

被引：96
作者：
Xiao, Yongwei [1 ,2 ]
Zheng, Lei [3 ]
Zou, Xiaofeng [4 ]
Wang, Jigang [2 ,5 ,6 ]
Zhong, Jianing [2 ,7 ]
Zhong, Tianyu [1 ,2 ,7 ]
机构：
[1] Gannan Med Univ, Lab Med, Affiliated Hosp 1, Ganzhou 341000, Peoples R China
[2] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrov, Minist Educ, Ganzhou 341000, Peoples R China
[3] Southern Med Univ, Nanfang Hosp, Lab Med, Guangzhou, Guangdong, Peoples R China
[4] Gannan Med Univ, Urol, Affiliated Hosp 1, Ganzhou, Peoples R China
[5] China Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing, Peoples R China
[6] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
[7] Gannan Med Univ, Precis Med Ctr, Affiliated Hosp 1, Ganzhou, Peoples R China
来源：
JOURNAL OF EXTRACELLULAR VESICLES | 2019年 / 8卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Extracellular vesicles; type 2 diabetes mellitus; pathogenesis; complications; therapy; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; EXOSOMAL MIRNAS; SKELETAL-MUSCLE; MOUSE MODEL; IN-VITRO; ANGIOGENESIS; BIOGENESIS; MICROVESICLES; DYSFUNCTION;
D O I：
10.1080/20013078.2019.1625677
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Type 2 diabetes mellitus (T2DM), a chronic disease, is widely prevalent all over the world. In recent years, the roles of some extracellular vesicles (EVs) in T2DM have attracted much attention. EVs are bilayer membrane vesicles secreted from most cells and can participate in regulating various physiological and pathological processes in vivo by being transported between cells. Recently, it was discovered that some abnormal EVs can contribute to the occurrence of T2DM by inducing insulin resistance and can also participate in the complications of T2DM. In addition, some stem/progenitor cells-derived EVs have a potential application in the therapy of T2DM. This review introduces basic concepts of EVs and summarizes the roles of EVs in the pathogenesis, complications, and therapy of T2DM.
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页数：14
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