Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol (vol 157, pg 679, 2016)

被引：1

作者：

Yasrebi, Ali ^{[1
]}

Hsieh, Anna ^{[1
]}

Mamounis, Kyle J. ^{[1
,2
]}

Krumm, Elizabeth A. ^{[1
,3
]}

Yang, Jennifer A. ^{[1
,3
]}

Magby, Jason ^{[1
]}

Hu, Pu ^{[1
]}

Roepke, Troy A. ^{[1
,2
,3
,4
]}

机构：

[1] Rutgers State Univ, Dept Anim Sci, Sch Environm & Biol Sci, New Brunswick, NJ 08903 USA

[2] Rutgers State Univ, Nutr Sci Grad Program, New Brunswick, NJ 08903 USA

[3] Rutgers State Univ, Grad Program Endocrinol & Anim Biosci, New Brunswick, NJ 08903 USA

[4] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08903 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2016年 / 428卷 / 0C期

关键词：

17β-Estradiol; Arcuate nucleus; Diet-induced obesity; Fasting; Ghrelin; Neuropeptide y;

D O I：

10.1016/j.mce.2016.04.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ghrelin's receptor, growth hormone secretagogue receptor (GHSR), is highly expressed in the arcuate nucleus (ARC) and in neuropeptide Y (NPY) neurons. Fasting, diet-induced obesity (DIO), and 17 beta-estradiol (E2) influence ARC Ghsr expression. It is unknown if these effects occur in NPY neurons. Therefore, we examined the expression of Npy, Agrp, and GHSR signaling pathway genes after fasting, DIO, and E2 replacement in ARC and pools of NPY neurons. In males, fasting increased ARC Ghsr and NPY Foxo1 but decreased NPY Ucp2. In males, DIO decreased ARC and NPY Ghsr and Cpt1c. In fed females, E2 increased Agrp, Ghsr, Cpt1c, and Foxo1 in ARC. In NPY pools, E2 decreased Foxo1 in fed females but increased Foxo1 in fasted females. DIO in females suppressed Agrp and augmented Cpt1c in NPY neurons. In summary, genes involved in GHSR signaling are differentially regulated between the ARC and NPY neurons in a sex-dependent manner. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：171 / 173

页数：3