Metal-Free Ring Opening Cyclization of Cyclopropane Carbaldehydes and N-Benzyl Anilines: An Eco-Friendly Access to Functionalized Benzo[b]azepine Derivatives

被引：22

作者：

Dey, Raghunath ^{[1
]}

Banerjee, Prabal ^{[1
]}

机构：

[1] Indian Inst Technol Ropar, Dept Chem, Nangal Rd, Rupnagar 140001, Punjab, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 12期

关键词：

cyclopropane carbaldehyde; N-benzyl aniline; metal-free ring opening cyclization; benzo[b]azepine; DONOR-ACCEPTOR CYCLOPROPANES; SUBSTITUTED CYCLOPROPANE; 3+2 CYCLOADDITION; ACID; ALKYNES;

D O I：

10.1002/adsc.201801714

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, we report a p-toluenesulfonic acid (PTSA) initiated mild and user-friendly ring opening/domino ring opening cyclization reaction (depends on substituent present in N-benzyl aniline) of cyclopropane carbaldehyde and N-benzyl aniline towards the formation of substituted 4-amino butanal/2,3-dihydro-1H-benzo[b]azepine. The product dihydro-1H-benzo[b]azepine was also converted into the corresponding tetrahydro-1H-benzo[b]azepine.

引用

页码：2849 / 2854

页数：6

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