Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.

被引：13

作者：

Kapojos, Magie M. ^{[1
,2
]}

Abdjul, Delfly B. ^{[1
,3
,4
]}

Yamazaki, Hiroyuki ^{[1
]}

Ohshiro, Taichi ^{[6
]}

Rotinsulu, Henki ^{[1
,5
]}

Wewengkang, Defny S. ^{[1
,5
]}

Sumilat, Deiske A. ^{[1
,4
]}

Tomoda, Hiroshi ^{[6
]}

Namikoshi, Michio ^{[1
]}

Uchida, Ryuji ^{[1
]}

机构：

[1] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9818558, Japan

[2] Univ Pembangunan Indonesia, Fac Nursing, Bahu 95115, Manado, Indonesia

[3] North Sulawesi Res & Dev Agcy, 17 Agustus St, Manado 95117, Indonesia

[4] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Kampus Bahu, Manado 95115, Indonesia

[5] Sam Ratulangi Univ, Fac Math & Nat Sci, Kampus Bahu, Manado 95115, Indonesia

[6] Kitasato Univ, Grad Sch Pharmaceut Sci, Tokyo 1088641, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 10期

关键词：

Callyspongiamide; Polychlorme-contammg modified dipeptide; Marine sponge Callyspongia sp; Sterol O-acyltransferase; Inhibitor; DYSIDEA SP; CHLORINATED PEPTIDES; NATURAL-PRODUCTS; DIKETOPIPERAZINES; ALKALOIDS; FRAGILIS;

D O I：

10.1016/j.bmcl.2018.03.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). The structures of 1 and 2 were elucidated to be polychlorine-containing modified dipeptides based on their spectroscopic data. Compounds 1-3 inhibited both of the SOAT isozymes, SOAT1 and SOAT2, in cell-based and enzyme-based assays. (C) 2018 Published by Elsevier Ltd.

引用

页码：1911 / 1914

页数：4

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