The dysfunction of T follicular helper cells

被引：19

作者：

Cubas, Rafael ^{[1
]}

Perreau, Matthieu ^{[2
,3
]}

机构：

[1] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA

[2] Univ Lausanne, Div Immunol, Univ Lausanne Hosp, Lausanne, Switzerland

[3] Univ Lausanne, Div Allergy, Univ Lausanne Hosp, Lausanne, Switzerland

来源：

CURRENT OPINION IN HIV AND AIDS | 2014年 / 9卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

B cells and dysfunction; HIV; T follicular helper; MEMORY B-CELLS; IMMUNODEFICIENCY VIRUS-INFECTION; CXC CHEMOKINE RECEPTOR-5; CHRONIC HIV-INFECTION; GERMINAL CENTER B; TRANSCRIPTION FACTOR; MONOCLONAL-ANTIBODY; LATENT RESERVOIR; IL-21; RECEPTOR; VIRAL LOAD;

D O I：

10.1097/COH.0000000000000095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Purpose of review T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody responses. Recent findings Recent studies have shown that HIV/simian immunodeficiency virus (SIV) infection affects both Tfh-cell frequency and function and suggest that Tfh-cell perturbations might contribute to the relative inefficiency of HIV-infected individuals to generate broadly neutralizing antibodies (bNAbs). Summary The present review will highlight these recent findings addressing the role of Tfh cells in HIV infection as well as the impact HIV infection has on Tfh and circulating memory Tfh (cTfh) cell frequency and function.

引用

页码：485 / 491

页数：7

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