Cell death after traumatic brain injury: Detrimental role of anoikis in healing

被引：11

作者：

Sater, Alexandre P. ^{[1
]}

Rael, Leonard T. ^{[1
,2
,3
,4
,5
,6
]}

Tanner, Allen H. ^{[4
]}

Lieser, Mark J. ^{[5
]}

Acuna, David L. ^{[6
]}

Mains, Charles W. ^{[2
]}

Bar-Or, David ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Swedish Med Ctr, Trauma Res Dept, 501 E Hampden Ave,Room 4-454, Englewood, CO 80113 USA

[2] St Anthony Hosp, Lakewood, CO 80228 USA

[3] Med City Plano, Plano, TX 75075 USA

[4] Penrose Community Hosp, Colorado Springs, CO 80907 USA

[5] Res Med Ctr, Kansas City, MO 64132 USA

[6] Wesley Med Ctr, Wichita, KS 67214 USA

来源：

CLINICA CHIMICA ACTA | 2018年 / 482卷

关键词：

Anoikis; Traumatic brain injury; Apoptosis; Blood-brain barrier; Matrix metalloproteinase; Caspase; MATRIX METALLOPROTEINASES; BARRIER DISRUPTION; APOPTOSIS; MECHANISMS; EXPRESSION; BLOOD; NEUROPROTECTION; ADHESION; ALPHA; GAMMA;

D O I：

10.1016/j.cca.2018.04.008

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Within the first few hours of a traumatic brain injury, the activity of extracellular matrix degradative enzymes increases. As a result, the blood brain barrier becomes disrupted as secondary white matter injury increases. Anoikis, a form of apoptosis, results from cells detaching from the extracellular matrix leading to cell death. This "homelessness" (anoikis) of cells hinders recovery progression, exacerbating brain injury while disrupting synaptic plasticity and other central nervous system functions. Here, we discuss the current knowledge of molecular pathways and proteins involved in both the activation and inhibition of anoikis.

引用

页码：149 / 154

页数：6

共 53 条

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