CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers

被引：93
作者：
Ramdzan, Zubaidah M. [1 ]
Nepveu, Alain p [1 ,2 ,3 ,4 ]
机构：
[1] McGill Univ, Goodman Canc Ctr, Montreal, PQ H3A 1A3, Canada
[2] McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3, Canada
[3] McGill Univ, Dept Med, Montreal, PQ H3A 1A3, Canada
[4] McGill Univ, Dept Oncol, Montreal, PQ H3A 1A3, Canada
来源：
NATURE REVIEWS CANCER | 2014年 / 14卷 / 10期
基金：
加拿大健康研究院;
关键词：
CCAAT-DISPLACEMENT PROTEIN; FACTOR HINF-D; CDP/CUX TRANSCRIPTION FACTOR; CUT HOMEODOMAIN PROTEIN; CELL-BASED ASSAYS; TRANSGENIC MICE; S-PHASE; UTERINE LEIOMYOMAS; MYELOID-LEUKEMIA; DNA-BINDING;
D O I：
10.1038/nrc3805
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and progression. The accumulated evidence supports a model of haploinsufficiency whereby reduced CUM expression promotes tumour development. Paradoxically, increased CUX1 expression is associated with tumour progression, and ectopic CUX1 expression in transgenic mice increases tumour burden in several tissues. One CUX1 isoform functions as an ancillary factor in base excision repair and the other CUX1 isoforms act as transcriptional activators or repressors. Several transcriptional targets and cellular functions of CUX1 affect tumorigenesis; however, we have yet to develop a mechanistic framework to reconcile the opposite roles of CUX1 in cancer protection and progression.
引用
收藏
页码：673 / 682
页数：10
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