Synthesis of 3-Nitro-2-arylimidazo[1,2-a]pyridines Using Sodium Dichloroiodide

被引：16

作者：

Jagadhane, Prashant B. ^{[1
]}

Telvekar, Vikas N. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

来源：

SYNLETT | 2014年 / 25卷 / 18期

关键词：

2-aminopyridine; nitrostyrene; iodine reagent; 3-nitro-2-arylimidazo[1,2-a]pyridines; DERIVATIVES; DESIGN; EXPLORATION; INHIBITORS; POTENT; AIR;

D O I：

10.1055/s-0034-1379185

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Moderate to good yields of various 3-nitro-2-arylimidazo[1,2-a]pyridines have been easily achieved in the reaction of 2-aminopyridines and nitrostyrenes in the presence of sodium dichloriodide. The procedure is simple and various functional groups are tolerated in this reaction system.

引用

页码：2636 / 2638

页数：3

共 23 条

[1] RESEARCH ON HETEROCYCLIC-COMPOUNDS .32. SYNTHESIS AND CYCLOOXYGENASE-INDEPENDENT ANTIINFLAMMATORY AND ANALGESIC ACTIVITY OF IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES [J].

ABIGNENTE, E ;

SACCHI, A ;

LANERI, S ;

ROSSI, F ;

DAMICO, M ;

BERRINO, L ;

CALDERARO, V ;

PARRILLO, C .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1994, 29 (04) :279-286

[2] Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs [J].

Al-Tel, Taleb H. ;

Al-Qawasmeh, Raed A. ;

Zaarour, Rania .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (05) :1874-1881

[3] N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase [J].

Baviskar, Ashish T. ;

Madaan, Chetna ;

Preet, Ranjan ;

Mohapatra, Purusottam ;

Jain, Vaibhav ;

Agarwal, Amit ;

Guchhait, Sankar K. ;

Kundu, Chanakya N. ;

Banerjee, Uttam C. ;

Bharatam, Prasad V. .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (14) :5013-5030

[4] Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2-and C3-functionalized imidazo[1,2-a]pyridines [J].

Bazin, Marc-Antoine ;

Marhadour, Sophie ;

Tonnerre, Alain ;

Marchand, Pascal .

TETRAHEDRON LETTERS, 2013, 54 (39) :5378-5382

[5] Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors [J].

Bode, Moira L. ;

Gravestock, David ;

Moleele, Simon S. ;

van der Westhuyzen, Christiaan W. ;

Pelly, Stephen C. ;

Steenkamp, Paul A. ;

Hoppe, Heinrich C. ;

Khan, Tasmiyah ;

Nkabinde, Lindiwe A. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (14) :4227-4237

[6] Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents [J].

Fu, Rong-geng ;

You, Qi-dong ;

Yang, Lei ;

Wu, Wu-tong ;

Jiang, Cheng ;

Xu, Xiao-li .

BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (22) :8035-8043

[7] Imidazopyridine-fused [1,3] -diazepinones: Synthesis and antiproliferative activity [J].

Gallud, Audrey ;

Vaillant, Ophelie ;

Maillard, Ludovic T. ;

Arama, Dominique P. ;

Dubois, Joelle ;

Maynadier, Marie ;

Lisowski, Vincent ;

Garcia, Marcel ;

Martinez, Jean ;

Masurier, Nicolas .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 75 :382-390

[8] Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates [J].

Hernandez, Paola ;

Rojas, Rosario ;

Gilman, Robert H. ;

Sauvain, Michel ;

Lima, Lidia M. ;

Barreiro, Eliezer J. ;

Gonzalez, Mercedes ;

Cerecetto, Hugo .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 59 :64-74

[9] Three-component direct synthesis of substituted pyrroles from easily accessible chemical moieties using hypervalent iodine reagent [J].

Jadhav, Nikhil C. ;

Jagadhane, Prashant B. ;

Patile, Hemlata V. ;

Telvekar, Vikas N. .

TETRAHEDRON LETTERS, 2013, 54 (23) :3019-3021

[10] Synthesis of GABAA receptor agonists and evaluation of their α-subunit selectivity and orientation in the GABA binding site [J].

Jansen, Michaela ;

Rabe, Holger ;

Strehle, Axelle ;

Dieler, Sandra ;

Debus, Fabian ;

Dannhardt, Gerd ;

Akabas, Myles H. ;

Lueddens, Hartmut .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (15) :4430-4448

← 1 2 3 →