Comparison of Renal Biomarkers with Glomerular Filtration Rate in Susceptibility to the Detection of Gentamicin-Induced Acute Kidney Injury in Dogs

被引：27

作者：

Sasaki, A. ^{[1
]}

Sasaki, Y. ^{[1
]}

Iwama, R. ^{[1
]}

Shimamura, S. ^{[1
]}

Yabe, K. ^{[2
]}

Takasuna, K. ^{[2
]}

Ichijo, T. ^{[1
]}

Furuhama, K. ^{[1
]}

Satoh, H. ^{[1
]}

机构：

[1] Iwate Univ, Cooperat Dept Vet Med, Morioka, Iwate 0208550, Japan

[2] Daiichi Sankyo Co Ltd, Med Safety Res Labs, Edogawa Ku, Tokyo, Japan

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2014年 / 151卷 / 2-3期

关键词：

dog; gentamicin; glomerular filtration rate; kidney injury; GELATINASE-ASSOCIATED LIPOCALIN; CREATININE; NEPHROTOXICITY; CLEARANCE; FAILURE; PROTEIN; MARKER;

D O I：

10.1016/j.jcpa.2014.06.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Fourteen renal biomarkers were compared with measurement of glomerular filtration rate (GFR) in detecting acute kidney injury (AKI) in beagle dogs given gentamicin (40 mg/kg/day by subcutaneous injection) for 7 consecutive days. Serum and urinary biomarkers were measured before administration of gentamicin and then on days 4 and 8 after starting administration. GFR was derived by use of a simplified equation. Increased urinary cystatin C and decreased GFR occurred from day 4 and were detected before increases in blood urea nitrogen (BUN) and serum creatinine concentrations and changes in other urinary parameters. The closest correlation was between urinary cystatin C and GFR. At termination, microscopical examination revealed extensive necrosis of proximal tubular epithelium with hyaline casts in the kidney of treated dogs. These data indicate that urinary cystatin C is the most sensitive index of kidney injury and GFR reflects the kidney functional mass. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：264 / 270

页数：7

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