Retinal Tissue Perfusion in Patients with Multiple Sclerosis

被引:9
作者
Liu, Yi [1 ,2 ]
Delgado, Silvia [3 ]
Jiang, Hong [2 ,3 ]
Lin, Ying [2 ,4 ]
Hernandez, Jeffrey [3 ]
Deng, Yuqing [2 ,4 ]
Gameiro, Giovana Rosa [2 ]
Wang, Jianhua [2 ]
机构
[1] Nanjing Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 3, Nanjing, Jiangsu, Peoples R China
[2] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, 1638 NW 10th Ave,McKnight Bldg Room 202A, Miami, FL 33136 USA
[3] Univ Miami, Miller Sch Med, MS Ctr Excellence, Dept Neurol, Miami, FL 33136 USA
[4] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Guangdong, Peoples R China
关键词
Retinal tissue perfusion (RTP); multiple sclerosis; retinal blood flow volume; retinal tissue volume; OPTICAL COHERENCE TOMOGRAPHY; NERVE-FIBER LAYER; BLOOD-FLOW; BRAIN ATROPHY; CEREBRAL HYPOPERFUSION; IMPAIRMENT; METABOLISM; MECHANISMS; THICKNESS; PATHOLOGY;
D O I
10.1080/02713683.2019.1612444
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: The goal of this work was to determine whether the retinal tissue perfusion (RTP) is impaired in patients with multiple sclerosis (MS). Methods: Seventy-four patients [66 relapsing-remitting MS (RRMS) and 8 clinically isolated syndrome (CIS)] and 74 age- and gender-matched healthy controls were recruited. RTP was calculated as the retinal blood flow (measured using retinal function imager) supplying the macular area divided by the corresponding tissue volume of the inner retina from the inner limiting membrane to the outer plexiform layer, as measured by ultrahigh-resolution optical coherence tomography. Results: The RTP in the MS group was 2.37 +/- 0.59 nl/s/mm(3) (mean +/- standard deviation), which was significantly lower than the control group (4.06 +/- 0.89 nl/s/mm(3), P < .001), reflecting a decrease of 42%. The blood flow volume was 2.50 +/- 0.50 nl/s in MS, which was 45% lower than in the control group (4.56 +/- 0.91 nl/s, P < .001). In addition, the tissue volume of the inner retina was significantly lower than in the control group (P < .05). The RTP in patients with MS was significantly correlated with the retinal blood flow volume (r = 0.84, P < .001) and retinal tissue volume (r = -0.56, P < .001). However, the retinal blood flow in patients with MS was not related to the tissue volume (r = -0.06, P = .59). Conclusions: Impaired retinal tissue perfusion occurred in patients with MS, which could be developed as a possible biomarker in monitoring disease progression in MS.
引用
收藏
页码:1091 / 1097
页数:7
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