Dynamic karyotype, dynamic proteome: buffering the effects of aneuploidy

被引：22

作者：

Donnelly, Neysan ^{[1
]}

Storchova, Zuzana ^{[1
,2
]}

机构：

[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[2] Ctr Integrated Prot Sci Munich, Munich, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2014年 / 1843卷 / 02期

关键词：

Genome stability; Genome dynamics; Gene expression; Proteomics; N-TERMINAL ACETYLATION; CHROMOSOMAL INSTABILITY; MOLECULAR CHAPERONES; SACCHAROMYCES-CEREVISIAE; GENOMIC INSTABILITY; 4TH CHROMOSOME; CELL-DIVISION; GENE DOSAGE; CONSEQUENCES; DEGRADATION;

D O I：

10.1016/j.bbamcr.2013.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite its ubiquity in cancer, link with other pathologies, and role in promoting adaptive evolution, the effects of aneuploidy or imbalanced chromosomal content on cellular physiology have remained incompletely characterized. Significantly, it appears that the detrimental as well as beneficial effects of aneuploidy are due to the altered gene expression elicited by the aneuploid state. In this review we examine the correlation between chromosome copy number changes and gene expression in aneuploid cells. We discuss the primary effects of aneuploidy on gene expression and describe the cellular response to altered mRNA and protein levels. Moreover, we consider compensatory mechanisms that may ameliorate imbalanced gene expression and restore protein homeostasis in aneuploid cells. Finally, we propose a novel hypothesis to explain the hitherto enigmatic abundance compensation of proteins encoded on supernumerary chromosomes. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：473 / 481

页数：9

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