Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study

被引：12

作者：

Rosso, Andrea L. ^{[1
]}

Metti, Andrea L. ^{[1
]}

Glynn, Nancy W. ^{[1
]}

Boudreau, Robert M. ^{[1
]}

Rejeski, W. Jack ^{[2
]}

Bohnen, Nicolaas ^{[3
,4
]}

Chen, Haiying ^{[5
]}

Johannsen, Neil M. ^{[6
]}

King, Abby C. ^{[7
]}

Manini, Todd M. ^{[8
]}

Pahor, Marco ^{[8
]}

Studenski, Stephanie A. ^{[9
]}

Fragoso, Carlos A. Vaz ^{[10
]}

Rosano, Caterina ^{[1
]}

机构：

[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA

[2] Wake Forest Univ, Dept Hlth & Exercise Sci, Winston Salem, NC 27109 USA

[3] Univ Michigan, Dept Neurol, Ann Arbor, MI USA

[4] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

[5] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[6] Louisiana State Univ, Sch Kinesiol, Baton Rouge, LA 70803 USA

[7] Stanford Univ, Dept Hlth Res & Policy, Palo Alto, CA 94304 USA

[8] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL USA

[9] NIA, Longitudinal Studies Sect, Baltimore, MD 21224 USA

[10] Yale Univ, Sch Med, Dept Geriatr, New Haven, CT USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2018年 / 66卷 / 06期

基金：

美国国家卫生研究院;

关键词：

randomized controlled trial; physical activity; aging; dopamine; LOWER-EXTREMITY FUNCTION; OLDER-ADULTS; EXERCISE; RECEPTOR; ADHERENCE; ASSOCIATION; RISK; AGE; POLYMORPHISMS; DISABILITY;

D O I：

10.1111/jgs.15369

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

ObjectivesTo determine whether intervention-induced physical activity (PA) changes in sedentary older adults differed according to dopamine-related genotype. DesignRandomized clinical trial (Lifestyle Interventions and Independence for Elders Trial (2010-13)). SettingMulticenter study, 8 U.S. locations. ParticipantsVolunteer sample of sedentary adults aged 70 to 89 at risk of disability (N=1635). InterventionsStructured PA versus health education (HE) for an average of 2.6 years. MeasurementsSingle-nucleotide polymorphisms of dopamine-related genes (dopamine receptor (DR) D1, DRD2, DRD3, and catechol-O-methyltransferase (COMT)) were assessed. Average moderate to vigorous PA (MVPA) was calculated using accelerometry (min/d) at baseline and 6, 12, and 24 months. Between-arm MVPA differences according to genotype and genotype with square root-transformed MVPA separately according to arm were tested, stratified according to race, and adjusted for multiple comparisons. ResultsWhite participants in the PA arm (n=513) had higher average square root transformed MVPA (4.911.91)than those in the HE arm (n=538) (4.511.82) (p=.001). Between-arm differences were greater for DRD2 Met/Met (high dopamine; HE: 4.76 +/- 1.80, PA: 5.53 +/- 1.60, p=.03) than Val/Val (low dopamine; HE: 4.58 +/- 1.92, PA: 4.81 +/- 1.83, p=.16); results were similar for COMT. In the PA arm, DRD2 Met/Met was associated with higher average MVPA (5.39 +/- 2.00) than Met/Val (4.46 +/- 2.51) (p=.01) and Val/Val (4.65 +/- 2.71) (p=.01). There were no associations for other genes. Associations were not significant in blacks but followed similar trends. ConclusionHigher dopamine signaling may support changes in PA during an intervention. The role of dopamine-related pathways in promoting PA participation and enhancing response to interventions in sedentary older adults should be studied. Trial Registration Identifier: NCT01072500

引用

页码：1172 / 1179

页数：8

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