The microcystins and nodularins: Cyclic polypeptide inhibitors of PP1 and PP2A

被引：69
作者：
Gulledge, BM
Aggen, JB
Huang, HB
Nairn, AC
Chamberlin, AR [1 ]
机构：
[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA
[2] Chu Tzi Coll Med, Inst Biochem, Hualien 970, Taiwan
[3] Rockefeller Univ, New York, NY 10021 USA
来源：
CURRENT MEDICINAL CHEMISTRY | 2002年 / 9卷 / 22期
关键词：
D O I：
10.2174/0929867023368845
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The serine/threonine phosphatases are inhibited by a variety of natural toxins, including the microcystins and nodularins. Progress in understanding the details of the biosynthetic origin and the binding of these compounds is discussed, as is the progress made in synthesizing the members of these families. Additionally, the work by several groups to either synthesize simplified analogues that are still potent, or introduce selectivity for PP1 over PP2A are discussed. Finally, the properties of a series of five new truncated analogues are examined.
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页码：1991 / 2003
页数：13
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