Characterization of cationic polyelectrolyte-induced domains in mixed POPG-POPC lipid bilayers via H-2 NMR

被引：24
|
作者：
Crowell, KJ
MacDonald, PM
机构：
[1] UNIV TORONTO,DEPT CHEM,TORONTO,ON M5S 1A2,CANADA
[2] UNIV TORONTO,ERINDALE COLL,TORONTO,ON M5S 1A2,CANADA
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 1997年 / 101卷 / 07期
关键词：
D O I：
10.1021/jp963284b
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The interactions of a cationic polyelectrolyte, poly(vinylbenzyltrimethylammonium chloride) (PVTA), with anionic lipid bilayer membranes composed of a mixture of phosphatidylglycerol (POPG) plus phosphatidylcholine (POPC) have been examined using H-2 NMR of choline-deuterated POPC to probe membrane surface electrostatics. PVTA produces distinct membrane domains containing a 1:1 PVTA/POPG cation/anion charge ratio. The remaining PVTA-free domains are depleted with respect to POPG.
引用
收藏
页码：1105 / 1109
页数：5
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