Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk

被引：9
作者：
Li, Chenyang [1 ]
Peng, Weijun [1 ,2 ]
Zhang, Heng [1 ,3 ]
Yan, Weirong [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Hosp Infect Management, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China
来源：
HYPERTENSION IN PREGNANCY | 2018年 / 37卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Angiotensin receptor 2; pregnancy induced hypertension; single nucleotide polymorphisms; haplotype analysis; BLOOD-PRESSURE; II TYPE-1; PREECLAMPSIA; AGTR2; POPULATION; EXPRESSION; DISORDERS;
D O I：
10.1080/10641955.2018.1460666
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. Results: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. Conclusions: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.
引用
收藏
页码：87 / 92
页数：6
相关论文
共 40 条
  • [1] Angiotensin II type 1 and 2 receptors gene polymorphisms in pre-eclampsia and normal pregnancy in three different populations
    Akbar, Syed Ali
    Khawaja, Nuzhat P.
    Brown, Paul R.
    Tayyeb, Rakhshanda
    Bamfo, Jacqueline
    Nicolaides, Kypros H.
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2009, 88 (05) : 606 - 611
  • [2] Blood Pressure in Different Gestational Trimesters, Fetal Growth, and the Risk of Adverse Birth Outcomes
    Bakker, Rachel
    Steegers, Eric A. P.
    Hofman, Albert
    Jaddoe, Vincent W. V.
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2011, 174 (07) : 797 - 806
  • [3] Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide
    Berry, C
    Touyz, R
    Dominiczak, AF
    Webb, RC
    Johns, DG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (06): : H2337 - H2365
  • [4] The classification and diagnosis of the hypertensive disorders of pregnancy: Statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)
    Brown, MA
    Lindheimer, MD
    de Swiet, M
    Van Assche, A
    Moutquin, JM
    [J]. HYPERTENSION IN PREGNANCY, 2001, 20 (01) : IX - XIV
  • [5] de Gasparo M, 2000, PHARMACOL REV, V52, P415
  • [6] Fox H, 1988, HDB HYPERTENSION, V10, P16
  • [7] Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia
    Geusens, N.
    Verlohren, S.
    Luyten, C.
    Taube, M.
    Hering, L.
    Vercruysse, L.
    Hanssens, M.
    Dudenhausen, J. W.
    Dechend, R.
    Pijnenborg, R.
    [J]. PLACENTA, 2008, 29 (07) : 614 - 623
  • [8] Hopkins MP, 2000, AM J OBSTET GYNECOL, V183, P1
  • [9] Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis
    Horiuchi, M
    Hayashida, W
    Kambe, T
    Yamada, T
    Dzau, VJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (30) : 19022 - 19026
  • [10] Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring The Helsinki Birth Cohort Study
    Kajantie, Eero
    Eriksson, Johan G.
    Osmond, Clive
    Thornburg, Kent
    Barker, David J. P.
    [J]. STROKE, 2009, 40 (04) : 1176 - 1180
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