Effects of the combination of methylprednisolone with aminoguanidine on functional recovery in rats following spinal cord injury

被引：6
作者：
Li, Zongshu [1 ,2 ]
Du, Juan [3 ]
Sun, Hongxia [2 ]
Mang, Jing [1 ]
He, Jinting [1 ]
Wang, Jiaoqi [1 ]
Liu, Hongyu [1 ]
Xu, Zhongxin [1 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Dept Neurol, Changchun 130033, Jilin, Peoples R China
[2] Jilin Prov Peoples Hosp, Dept Neurol, Changchun 130021, Jilin, Peoples R China
[3] Jilin Univ, China Japan Union Hosp, Dept Rheumatol & Immunol, Changchun 130033, Jilin, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2014年 / 7卷 / 06期
关键词：
spinal cord injury; methylprednisolone; aminoguanidine; functional recovery; NITRIC-OXIDE; GLUTAMATE RELEASE; MESSENGER-RNA; BRAIN-INJURY; INFLAMMATION; RECEPTOR; MICROGLIA; MICE; INHIBITION; ASTROCYTES;
D O I：
10.3892/etm.2014.1613
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Methylprednisolone (MP), a synthetic glucocorticoid, has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). The combination of MP and other pharmacological agents aimed at enhancing functional recovery is desirable as the beneficial effects of MP are controversial, due to a variety of side-effects. Aminoguanidine (AG), a small water-soluble compound, is potentially useful in the treatment of acute SCI. The aim of the present study was to determine the effects of MP and AG, administered in combination, following SCI in adult rats. In rats with SCI, the combination therapy group treated with AG (75 mg/kg) and MP (0.75 mg/kg) exhibited significantly reduced levels of cytokine expression and cell apoptosis compared with those in the control group. In addition, the data demonstrated that the combination therapy significantly enhanced the recovery of limb function. These data clearly suggest that treatment with a combination of MP and AG represents a promising strategy of clinically applicable pharmacological therapy for the rapid initiation of neuroprotection following SCI.
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收藏
页码：1605 / 1610
页数：6
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