Time dependence of material properties of polyethylene glycol hydrogels chain extended with short hydroxy acid segments

被引：22
作者：
Barati, Danial [1 ]
Moeinzadeh, Seyedsina [1 ]
Karaman, Ozan [1 ]
Jabbari, Esmaiel [1 ]
机构：
[1] Univ S Carolina, Dept Chem Engn, Biomimet Mat & Tissue Engn Lab, Columbia, SC 29208 USA
来源：
POLYMER | 2014年 / 55卷 / 16期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Hydrogel chain extension; Hydroxy acids; Cell encapsulation; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; BULK-DEGRADATION MODEL; OSTEOGENIC DIFFERENTIATION; GELATION CHARACTERISTICS; NANOSTRUCTURE; PEPTIDES; POLYMERS; SCAFFOLD; NETWORKS;
D O I：
10.1016/j.polymer.2014.05.045
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The objective of this work was to investigate the effect of chemical composition and segment number (n) on gelation, stiffness, and degradation of hydroxy acid-chain-extended star polyethylene glycol acrylate (SPEXA) gels. The hydroxy acids included glycolide (G), L-lactide (L), p-dioxanone (D) and c-caprolactone (C). Chain-extension generated water soluble macromers with faster gelation rates, lower sol fractions, higher compressive moduli, and a wide-ranging degradation times when crosslinked into a hydrogel. SPEGA gels with the highest fraction of inter-molecular crosslinks had the most increase in compressive modulus with n whereas SPELA and SPECA had the lowest increase in modulus. SPEXA gels exhibited a wide range of degradation times from a few days for SPEGA to a few weeks for SPELA, a few months for SPEDA, and many months for SPECA. Marrow stromal cells and endothelial progenitor cells had the highest expression of vasculogenic markers when co-encapsulated in the faster degrading SPELA gel. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3894 / 3904
页数：11
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