Time dependence of material properties of polyethylene glycol hydrogels chain extended with short hydroxy acid segments

被引：22
作者：
Barati, Danial [1 ]
Moeinzadeh, Seyedsina [1 ]
Karaman, Ozan [1 ]
Jabbari, Esmaiel [1 ]
机构：
[1] Univ S Carolina, Dept Chem Engn, Biomimet Mat & Tissue Engn Lab, Columbia, SC 29208 USA
来源：
POLYMER | 2014年 / 55卷 / 16期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Hydrogel chain extension; Hydroxy acids; Cell encapsulation; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; BULK-DEGRADATION MODEL; OSTEOGENIC DIFFERENTIATION; GELATION CHARACTERISTICS; NANOSTRUCTURE; PEPTIDES; POLYMERS; SCAFFOLD; NETWORKS;
D O I：
10.1016/j.polymer.2014.05.045
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The objective of this work was to investigate the effect of chemical composition and segment number (n) on gelation, stiffness, and degradation of hydroxy acid-chain-extended star polyethylene glycol acrylate (SPEXA) gels. The hydroxy acids included glycolide (G), L-lactide (L), p-dioxanone (D) and c-caprolactone (C). Chain-extension generated water soluble macromers with faster gelation rates, lower sol fractions, higher compressive moduli, and a wide-ranging degradation times when crosslinked into a hydrogel. SPEGA gels with the highest fraction of inter-molecular crosslinks had the most increase in compressive modulus with n whereas SPELA and SPECA had the lowest increase in modulus. SPEXA gels exhibited a wide range of degradation times from a few days for SPEGA to a few weeks for SPELA, a few months for SPEDA, and many months for SPECA. Marrow stromal cells and endothelial progenitor cells had the highest expression of vasculogenic markers when co-encapsulated in the faster degrading SPELA gel. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3894 / 3904
页数：11
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共 50 条
[1]   The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype [J].
Adeloew, Catharina ;
Segura, Tatiana ;
Hubbell, Jeffrey A. ;
Frey, Peter .
BIOMATERIALS, 2008, 29 (03) :314-326
[2]   MOLECULAR AND CELLULAR PROPERTIES OF PECAM-1 (ENDOCAM/CD31) - A NOVEL VASCULAR CELL CELL-ADHESION MOLECULE [J].
ALBELDA, SM ;
MULLER, WA ;
BUCK, CA ;
NEWMAN, PJ .
JOURNAL OF CELL BIOLOGY, 1991, 114 (05) :1059-1068
[3]   Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A [J].
Bautch, VL ;
Redick, SD ;
Scalia, A ;
Harmaty, M ;
Carmeliet, P ;
Rapoport, R .
BLOOD, 2000, 95 (06) :1979-1987
[4]   Regulating myoblast phenotype through controlled gel stiffness and degradation [J].
Boontheekul, Tanyarut ;
Hill, Elliott E. ;
Kong, Hyun-Joon ;
Mooney, David J. .
TISSUE ENGINEERING, 2007, 13 (07) :1431-1442
[5]   Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels [J].
Bryant, SJ ;
Anseth, KS .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 59 (01) :63-72
[6]   Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage [J].
Bryant, SJ ;
Anseth, KS .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 64A (01) :70-79
[7]   The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening [J].
Chatterjee, Kaushik ;
Lin-Gibson, Sheng ;
Wallace, William E. ;
Parekh, Sapun H. ;
Lee, Young Jong ;
Cicerone, Marcus T. ;
Young, Marian F. ;
Simon, Carl G., Jr. .
BIOMATERIALS, 2010, 31 (19) :5051-5062
[8]  
Chen KL, 2012, TISSUE ENG PT A, V18, P1399, DOI [10.1089/ten.tea.2011.0376, 10.1089/ten.TEA.2011.0376]
[9]   Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels [J].
Chen, Ying-Chieh ;
Lin, Ruei-Zeng ;
Qi, Hao ;
Yang, Yunzhi ;
Bae, Hojae ;
Melero-Martin, Juan M. ;
Khademhosseini, Ali .
ADVANCED FUNCTIONAL MATERIALS, 2012, 22 (10) :2027-2039
[10]   NETWORK STRUCTURES OF RADIATION-CROSS-LINKED STAR POLYMER GELS [J].
CIMA, LG ;
LOPINA, ST .
MACROMOLECULES, 1995, 28 (20) :6787-6794
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