Diterpenoids from Isodon pharicus

被引：19

作者：

Zhao, Yong ^{[1
,2
]}

Huang, Sheng-Xiong ^{[1
]}

Xiao, Wei-Lie ^{[1
]}

Ding, Li-Sheng ^{[3
]}

Pu, Jian-Xin ^{[1
]}

Li, Xian ^{[1
]}

Yang, Li-Bin ^{[1
]}

Sun, Han-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Yunnan Normal Univ, Coll Chem & Engn, Kunming 650092, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 17期

关键词：

Isodon pharicus; Labiatae; Bispseurata F; Pharicinins A-C; NMR data; Cytotoxicity; RABDOSIA-PSEUDO-IRRORATA; RUBESCENS;

D O I：

10.1016/j.tetlet.2009.02.102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A phytochemical investigation of Isodon pharicus led to the isolation of a novel asymmetric ent-kauranoid dimer, bispseurata F (1), and three new diterpenoids, pliaricinins A-C (2-4). Their structures were elucidated by extensive spectroscopic analysis. Compound 1 features a unique linkage pattern of C-17 with C-11' to connect the two monomers. A possible biogenetic pathway of 1 was also proposed. Compounds 3 and 4 exhibited moderate inhibitory activity against NB4 and SH-SY5Y cell lines. (C 2009 Elsevier Ltd. All rights reserved.

引用

页码：2019 / 2023

页数：5

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