Natural products remodel cancer-associated fibroblasts in desmoplastic tumors

被引：38

作者：

Chen, Rujing ^{[1
]}

Huang, Leaf ^{[2
]}

Hu, Kaili ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Murad Res Ctr Modernized Chinese Med, Shanghai 201203, Peoples R China

[2] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Div Pharmacoengn & Mol Pharmaceut, Chapel Hill, NC 27599 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2020年 / 10卷 / 11期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Natural products; Desmoplastic tumors; Cancer-associated fibroblasts; Tumor microenvironment; Extracellular matrix; Traditional Chinese medicine; Cancer treatment; HEPATIC STELLATE CELLS; RENAL INTERSTITIAL FIBROSIS; INDUCED PULMONARY-FIBROSIS; PANCREATIC-CANCER; ASTRAGALOSIDE IV; IN-VIVO; MESENCHYMAL TRANSITION; EXTRACELLULAR-MATRIX; PATHOLOGICAL FUNCTIONS; NAB-PACLITAXEL;

D O I：

10.1016/j.apsb.2020.04.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Desmoplastic tumors have an abundance of stromal cells and the extracellular matrix which usually result in therapeutic resistance. Current treatment prescriptions for desmoplastic tumors are usually not sufficient to eliminate the malignancy. Recently, through modulating cancer-associated fibroblasts (CAFs) which are the most abundant cell type among all stromal cells, natural products have improved chemotherapies and the delivery of nanomedicines to the tumor cells, showing promising ability to improve treatment effects on desmoplastic tumors. In this review, we discussed the latest advances in inhibiting desmoplastic tumors by modeling CAFs using natural products, highlighting the potential therapeutic abilities of natural products in targeting CAFs for cancer treatment. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：2140 / 2155

页数：16

共 121 条

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