Synthesis of α-Trifluoromethyl Ketones via the Cu-Catalyzed Trifluoromethylation of Silyl Enol Ethers Using an Electrophilic Trifluoromethylating Agent

被引：68

作者：

Li, Lun ^{[1
]}

Chen, Qing-Yun ^{[1
]}

Guo, Yong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 11期

基金：

中国国家自然科学基金;

关键词：

RADICAL TRIFLUOROMETHYLATION; ASYMMETRIC FLUORINATION; PERFLUOROALKYLATION; CHEMISTRY; REAGENTS; CARBONYL; PALLADIUM; EFFICIENT; RHODIUM; ARENE;

D O I：

10.1021/jo500713f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method has been developed for the synthesis of alpha-trifluoromethyl ketones via the Cu-catalyzed trifluoromethylation of silyl enol ethers with an electrophilic trifluoromethylating agent, which produces a trifluoromethyl radical.

引用

页码：5145 / 5152

页数：8

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