Cell is a component unit of organism which presents the complexity and factuality of life system. As a research object, it is possible to understand the chemical nature of some biological occurrences if the interactions between inorganic molecules and biological macromolecules in cell are studied. There are a lot of problems to be studied in this field, but at present the matters of related diseases severely threatening human health, such as diabetes mellitus, cardiovascular diseases, cancer, neuropathic degenerative diseases, should be taken precedence. It has important scientific significance and application value if the research project will be implemented, because it is propitious to understand structure-function relationship, prevent and cure some related diseases, comprehend the regulation mechanism of inorganic molecules to biological reactions, discover new target molecules of drug action, design and develop medicines. In this proposal, the research goal and contents are also given concretely.