Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay

被引：26

作者：

Zheng, Yue ^{[1
]}

Zhou, Jie ^{[1
]}

Sayre, David A. ^{[1
]}

Sintim, Herman O. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 76期

基金：

美国国家科学基金会;

关键词：

BACILLUS-SUBTILIS; 2ND-MESSENGER; FLUORESCENCE; TRANSPORTERS; RESISTANCE; PROTEIN; GROWTH;

D O I：

10.1039/c4cc02916j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

c-di-AMP is an important bacterial second messenger found in Gram-positive and mycobacteria. c-di-AMP regulates myriads of processes in bacteria as well as immune response in higher organisms so interest in small molecules that would attenuate the activity of c-di-AMP metabolism enzymes is high. Herein, we report the first small molecule inhibitor of a c-di-AMP synthase, DisA, using a coralyne-based assay.

引用

页码：11234 / 11237

页数：4

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