Overexpression of Mir-21-5p Induces Apoptosis and Cell Cycle Arrest By Down-Regulating SKP2 and Overcomes Bortezomib Resistance in Multiple Myeloma

被引:1
|
作者
William, Jonahunnatha Nesson George [1 ]
Wu, Jian [1 ]
Chen, Ziyan [1 ]
Faruq, Omar [1 ]
Chang, Hong [2 ]
机构
[1] Univ Hlth Network, Toronto, ON, Canada
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
关键词
D O I
10.1182/blood-2019-128917
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1823
引用
收藏
页数:3
相关论文
共 50 条
  • [1] A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2
    Knowles, LM
    Axelrod, F
    Browne, CD
    Smith, JW
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (29) : 30540 - 30545
  • [2] cAMP induces cell apoptosis in multiple myeloma and overcomes bortezomib resistance
    Wang, Yingying
    Tang, Yong
    Hang, Haifang
    Wang, Mingming
    Pang, Yuyang
    Yu, Yehua
    Wu, Yingli
    Zhu, Qi
    AMERICAN JOURNAL OF CANCER RESEARCH, 2018, 8 (01): : 16 - +
  • [3] Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells
    Koga, H
    Harada, M
    Ohtsubo, M
    Shishido, S
    Kumemura, H
    Hanada, S
    Taniguchi, E
    Yamashita, K
    Kumashiro, R
    Ueno, T
    Sata, M
    HEPATOLOGY, 2003, 37 (05) : 1086 - 1096
  • [4] miR-21-5p targets SKP2 to reduce osteoclastogenesis in a mouse model of osteoporosis
    Huang, Yizhen
    Yang, Yute
    Wang, Jianle
    Yao, Shasha
    Yao, Teng
    Xu, Yining
    Chen, Zizheng
    Yuan, Putao
    Gao, Jun
    Shen, Shuying
    Ma, Jianjun
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 296
  • [5] Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance
    Yao Yao
    Dandan Xia
    Yueping Bian
    Yueyue Sun
    Feng Zhu
    Bin Pan
    Mingshan Niu
    Kai Zhao
    Qingyun Wu
    Jianlin Qiao
    Chunling Fu
    Zhenyu Li
    Kailin Xu
    Apoptosis, 2015, 20 : 1122 - 1133
  • [6] Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance
    Yao, Yao
    Xia, Dandan
    Bian, Yueping
    Sun, Yueyue
    Zhu, Feng
    Pan, Bin
    Niu, Mingshan
    Zhao, Kai
    Wu, Qingyun
    Qiao, Jianlin
    Fu, Chunling
    Li, Zhenyu
    Xu, Kailin
    APOPTOSIS, 2015, 20 (08) : 1122 - 1133
  • [7] miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer
    Zhong, Zhiwei
    Dong, Zhuo
    Yang, Lihua
    Gong, Zhaohui
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2012, 138 (10) : 1781 - 1788
  • [8] miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer
    Zhiwei Zhong
    Zhuo Dong
    Lihua Yang
    Zhaohui Gong
    Journal of Cancer Research and Clinical Oncology, 2012, 138 : 1781 - 1788
  • [9] The Novel NFkB Inhibitor V1810 Induces Apoptosis and Cell Cycle Arrest in Multiple Myeloma Cells and Overcomes NFkB Mediated Drug Resistance
    Meinel, Felix
    Mandl-Weber, Sonja
    Baumann, Philipp
    Leban, Johann
    Schmidmaier, Ralf
    BLOOD, 2008, 112 (11) : 604 - 604
  • [10] Co-Treatment of Bortezomib and PRIMA-1Met Synergistically Overcomes Drug Resistance by Down-Regulating Pro-Survival Autophagy in Multiple Myeloma
    Wang, Minjing
    Zhang, Lun
    Rastgoo, Nasrin
    Abdi, Jahangir
    Chang, Hong
    MODERN PATHOLOGY, 2017, 30 : 383A - 384A