Targeting IL-10 in Auto-immune Diseases

被引：63

作者：

Tian, Guo ^{[1
]}

Li, Jiao-Long ^{[1
]}

Wang, De-Guang ^{[2
]}

Zhou, Dian ^{[1
,3
]}

机构：

[1] Anhui Med Univ, Sch Hlth Management, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 2, Dept Nephrol, Hefei 230032, Anhui, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 70卷 / 01期

关键词：

IL-10; Auto-immune diseases; Therapeutic target; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INTERLEUKIN-10 RECEPTOR EXPRESSION; CD4(+) T-CELLS; PROMOTER REGION POLYMORPHISMS; INHIBITS CYTOKINE PRODUCTION; B-LYMPHOCYTE HYPERACTIVITY; MESSENGER-RNA EXPRESSION; INNATE IMMUNE-RESPONSES; RHEUMATOID-ARTHRITIS; SJOGRENS-SYNDROME;

D O I：

10.1007/s12013-014-9903-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-10 is a multifunctional cytokine secreted by a variety of cells. It not only inhibits activation of monocyte/macrophage system and synthesis of monocyte cytokine and inflammatory cytokine but also promotes the proliferation and maturation of non-monocyte-dependent T cell, stimulating proliferation of antigen-specific B cell. Increasing evidence indicates that IL-10 plays an important role in both the onset and development of auto-immune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), multiple sclerosis (MS), Crohn's disease (CD), and psoriasis. However, the exact mechanisms of IL-10 in auto-immune diseases remain unclear. In the present review, we will summarize the biological effects of IL-10, as well as its role and therapeutic potential in auto-immune diseases.

引用

页码：37 / 49

页数：13

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