Immunological Role and Prognostic Value of APBB1IP in Pan-Cancer Analysis

被引：26
作者：
Ge, Qianyun [1 ,2 ]
Li, Ganxun [1 ,2 ]
Chen, Jin [1 ,2 ]
Song, Jia [1 ,2 ]
Cai, Guangzhen [1 ,2 ]
He, Yi [1 ,2 ]
Zhang, Xuewu [1 ,2 ]
Liang, Huifang [1 ,2 ]
Ding, Zeyang [1 ,2 ]
Zhang, Bixiang [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Jiefang Ave 1095, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hubei Key Lab HepatoPancreato Biliary Dis, Wuhan, Peoples R China
来源：
JOURNAL OF CANCER | 2021年 / 12卷 / 02期
关键词：
APBB1IP; pan-cancer analysis; immune infiltration; prognosis; tumor immune microenvironment; INTERACTION NETWORKS; INTEGRIN ACTIVATION; CELLS; GENE; EXPRESSION; REVEAL; TALIN; RIAM; PU.1; LYMPHOCYTES;
D O I：
10.7150/jca.50785
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: APBB1IP is a Rap1-binding protein that mainly acts as a regulator of leukocyte recruitment and pathogen clearance through complement-mediated phagocytosis. However, the role of APBB1IP in tumor immunity remains unclear. This study was carried out to evaluate the prognostic landscape of APBB1IP in pan-cancer analysis and investigate the relationship between APBB1IP expression and immune infiltration. Methods: We explored the expression pattern and prognostic value of APBB1IP in pan-cancer analysis through Kaplan-Meier Plotter and multiple databases, including TCGA, Oncomine. We then assessed the correlation between APBB1IP expression and immune cell infiltration using the TIMER database. Furthermore, we identified the proteins that interact with APBB1IP and performed epigenetic and transcriptional analyses. Multivariate Cox regression analyses were applied to construct a prognostic model, which consisted of APBB1IP and its interacting proteins, based on the lung cancer cohorts from the Gene Expression Omnibus (GEO) database. Results: The expression of APBB1IP was correlated with the prognosis of several types of cancer. APBB1IP upregulation was found to be associated with increased immune cell infiltration, especially for CD8(+) T cells, natural killer (NK) cells, and immune regulators. A link was found between APBB1IP and immune-related proteins including RAP1A/B, TLN1/2 and VCL in the interaction network. Conclusion: APBB1IP can serve as a prognostic biomarker in pan-cancer analysis. APBB1IP upregulation was correlated with increased immune-cell infiltration, and the expression APBB1IP in different tumors might be related to the tumor immune microenvironment.
引用
收藏
页码：595 / 610
页数：16
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