Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells

被引：36
作者：
Li, Rui [1 ]
Yang, Hong-Qiang [2 ]
Xi, Hai-Lin [2 ]
Feng, Su [2 ]
Qin, Rui-Hao [2 ]
机构：
[1] Southeast Univ, Affiliated Hosp, Xuzhou Med Coll, Dept Cent Lab,Xuzhou Cent Hosp,Xuzhou Clin Sch, Xuzhou 221009, Jiangsu, Peoples R China
[2] Southeast Univ, Affiliated Hosp, Xuzhou Med Coll, Dept Gen Surg,Xuzhou Cent Hosp,Xuzhou Clin Sch, 199 South Jiefang Rd, Xuzhou 221009, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2017年 / 50卷 / 01期
基金：
中国国家自然科学基金;
关键词：
gastric cancer; RNA interference; CDH17; proliferation; apoptosis; LIVER-INTESTINE-CADHERIN; LYMPH-NODE METASTASIS; LI-CADHERIN; TUMOR-GROWTH; CARCINOMA; METAPLASIA; CDX2; IDENTIFICATION; INVASIVENESS; MARKER;
D O I：
10.3892/ijo.2016.3783
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer is the fourth most common type of cancer and the second cause of cancer-related mortalities worldwide despite the use of multimodal therapy. Cadherins are transmembrane glycoproteins that are involved in tumorigenesis. CDH17 has been found to be over-expressed in gastric cancer and its overexpression was associated with lymph node metastasis and tumor-node-metastasis stage of the patients, yet the exact role and molecular mechanism of CDH17 in gastric cancer have not been determined. Using a lentiviral system as a delivery mediator of RNA interference, we found that inhibition of CDH17 can lead to reduce proliferation and increase apoptosis of gastric cancer cell line MKN28 in vitro and significantly diminish their tumorigenicity in vivo. Our results of the present study suggest that CDH17 may be a promising candidate for the therapeutic targeting of gastric cancer.
引用
收藏
页码：15 / 22
页数：8
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