The minipig in dermatotoxicology:: Methods and challenges

被引：51

作者：

Mahl, Joerg Andreas ^{[1
]}

Vogel, Beate E. ^{[1
]}

Court, Mireille ^{[1
]}

Kolopp, Maryelle ^{[1
]}

Roman, Danielle ^{[1
]}

Nogues, Vicente ^{[1
]}

机构：

[1] Novartis Pharm AG, CH-4132 Muttenz, Switzerland

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2006年 / 57卷 / 5-6期

关键词：

minipig; dermal administration methods; skin investigations; challenging aspects in dermatotoxicology;

D O I：

10.1016/j.etp.2006.03.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In view of more morphological and physiological similarities between human and porcine skin than for other laboratory animal species, the minipig is a preferred model to evaluate the safety profile of dermally applied xenobiotics. Different methods of dermal administration and examples of non-invasive and invasive investigations during the in-life phase of the studies are described. Routine and special post-mortem examinations in dermal studies are presented to assess responses to the topical treatment of minipig skin. Challenges in dermal minipig studies are discussed with respect to animal welfare and husbandry, test formulations, application methods and different types of investigations. One of the most significant issues for dermal minipig studies is the extensive measures required to prevent cross-contamination of blood and tissue samples taken to monitor local and systemic exposure to the test item. (c) 2006 Elsevier GmbH. All rights reserved.

引用

页码：341 / 345

页数：5

共 14 条

[1] Comparison of the effect of fatty alcohols on the permeation of melatonin between porcine and human skin [J].