New tumor regression grade for rectal cancer after neoadjuvant therapy and radical surgery

被引：3

作者：

Li, Jun ^{[1
]}

Liu, Hao ^{[2
]}

Hu, Junjie ^{[3
]}

Liu, Sai ^{[4
]}

Yin, Jie ^{[5
]}

Du, Feng ^{[6
,7
]}

Yuan, Jiatian ^{[1
]}

Lv, Bo ^{[1
]}

机构：

[1] Chengdu Univ, Clin Med Coll, Affiliated Hosp, Dept Gen Surg, Chengdu, Peoples R China

[2] Jilin Univ, Affiliated Hosp 2, Gen Surg Dept, Changchun 130023, Peoples R China

[3] Hubei Canc Hosp, Gastrointestinal Tumor Surg, Wuhan, Peoples R China

[4] Capital Med Univ, Beijing Youan Hosp, Surg Dept Gastrointestinal Dis, Beijing, Peoples R China

[5] Xuzhou Cent Hosp, Dept Gen Surg, Xuzhou, Peoples R China

[6] Peking Union Med Coll, Canc Inst Hosp, Internal Med Oncol, Beijing 100021, Peoples R China

[7] Chinese Acad Med Sci, Beijing 100730, Peoples R China

来源：

ONCOTARGET | 2015年 / 6卷 / 39期

关键词：

tumor regression grading; rectal cancer; neoadjuvant therapy; PATHOLOGICAL COMPLETE RESPONSE; PREOPERATIVE CHEMORADIOTHERAPY; CHEMORADIATION;

D O I：

10.18632/oncotarget.6008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this retrospective study, we defined a new tumor regression grade (NTRG), which we used to evaluate the prognosis of patients with locally advanced rectal cancer who received neoadjuvant therapy and then underwent radical surgery between June 2004 and October 2011. Calculated as the TRG plus a lymph node score, the NTRG was determined for 347 patients: NTRG 0, 46 patients (13.3%); NTRG 1, 63 (18.2%); NTRG 2, 183 (52.7%); NTRG 3, 30 (8.6%); NTRG 4, 25 (7.2%). Among this group, 45 (97.8%) NTRG 0, 56 (88.9%) NTRG 1, 148 (80.9%) NTRG 2, 24 (66.7%) NTRG 3, and 10 (40.0%) NTRG 4 patients experienced 5-year disease-free survival. We also found that NTRG is significantly associated with 5-year local recurrence, distant metastasis and disease-free survival (P = 0.004, 0.007 and 0.039, respectively). The NTRG may thus be an independent prognostic factor for oncologic outcomes in rectal cancer patients after neoadjuvant therapy and radical surgery, but this conclusion must be validated in randomized trials.

引用

页码：42222 / 42231

页数：10

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