Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

被引:17
|
作者
Stein, Gary S. [1 ]
Zaidi, Sayyed K. [1 ]
Stein, Janet L. [1 ]
Lian, Jane B. [1 ]
van Wijnen, Andre J. [1 ]
Montecino, Martin [2 ]
Young, Daniel W. [3 ]
Javed, Amjad [1 ]
Pratap, Jitesh [1 ]
Choi, Je-Yong [4 ]
Ali, Syed A. [1 ]
Pande, Sandhya [1 ]
Hassan, Mohammad Q. [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA
[2] Univ Concepcion, Dept Biol Mol, Fac Ciencias Biol, Concepcion 4079100, Chile
[3] Wolf Greenfield & Sacks, Boston, MA 02210 USA
[4] Kyungpook Natl Univ, Sch Med, Skeletal Dis Genome Res Ctr, Dept Biochem & Cell Biol, Taegu 700422, South Korea
来源
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 2009年 / 87卷 / 01期
关键词
cell cycle; nuclear microenvironment; gene expression; chromatin; Runx; intranuclear trafficking; BREAST-CANCER CELLS; HISTONE DEACETYLASE INHIBITORS; NUCLEAR MICROENVIRONMENTS; REGULATORY MACHINERY; INTRANUCLEAR TRAFFICKING; CHROMATIN ORGANIZATION; RUNX/CBFA/AML FACTORS; OSTEOCALCIN PROMOTER; BIOLOGICAL-CONTROL; TARGETING SIGNAL;
D O I
10.1139/O08-094
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetic control is required to maintain competency for the activation and Suppression of genes during Cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.
引用
收藏
页码:1 / 6
页数:6
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