Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

被引：17

作者：

Stein, Gary S. ^{[1
]}

Zaidi, Sayyed K. ^{[1
]}

Stein, Janet L. ^{[1
]}

Lian, Jane B. ^{[1
]}

van Wijnen, Andre J. ^{[1
]}

Montecino, Martin ^{[2
]}

Young, Daniel W. ^{[3
]}

Javed, Amjad ^{[1
]}

Pratap, Jitesh ^{[1
]}

Choi, Je-Yong ^{[4
]}

Ali, Syed A. ^{[1
]}

Pande, Sandhya ^{[1
]}

Hassan, Mohammad Q. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA

[2] Univ Concepcion, Dept Biol Mol, Fac Ciencias Biol, Concepcion 4079100, Chile

[3] Wolf Greenfield & Sacks, Boston, MA 02210 USA

[4] Kyungpook Natl Univ, Sch Med, Skeletal Dis Genome Res Ctr, Dept Biochem & Cell Biol, Taegu 700422, South Korea

来源：

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 2009年 / 87卷 / 01期

关键词：

cell cycle; nuclear microenvironment; gene expression; chromatin; Runx; intranuclear trafficking; BREAST-CANCER CELLS; HISTONE DEACETYLASE INHIBITORS; NUCLEAR MICROENVIRONMENTS; REGULATORY MACHINERY; INTRANUCLEAR TRAFFICKING; CHROMATIN ORGANIZATION; RUNX/CBFA/AML FACTORS; OSTEOCALCIN PROMOTER; BIOLOGICAL-CONTROL; TARGETING SIGNAL;

D O I：

10.1139/O08-094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetic control is required to maintain competency for the activation and Suppression of genes during Cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

引用

页码：1 / 6

页数：6

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