The Role of PON1 Variants in Disease Susceptibility in a Turkish Population

被引：8

作者：

Abudayyak, Mahmoud ^{[1
]}

Boran, Tugce ^{[1
]}

Tukel, Rumeysa ^{[1
]}

Oztas, Ezgi ^{[1
]}

Ozhan, Gul ^{[1
]}

机构：

[1] Istanbul Univ, Dept Pharmaceut Toxicol, Fac Pharm, Istanbul, Turkey

来源：

GLOBAL MEDICAL GENETICS | 2020年 / 7卷 / 02期

关键词：

paraoxonase-1; hypothyroidism; pancreatitis; SERUM PARAOXONASE ACTIVITY; LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; GENE POLYMORPHISMS; ANTIOXIDANT STATUS; INCREASED RISK; ASSOCIATION; HYPOTHYROIDISM; CANCER;

D O I：

10.1055/s-0040-1715568

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. PON1 genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 G allele had a two-fold risk of developing hypothyroidism. A weak association was found between rs854560 T allele and pancreatitis. The results were preliminary. Further studies with a larger number and detailed biochemical parameters are needed.

引用

页码：41 / 46

页数：6

共 47 条

[1] Exploring the Role of Paraoxonases in the Pathogenesis of Coronary Artery Disease: A Systematic Review [J].

Abello, David ;

Sancho, Elena ;

Camps, Jordi ;

Joven, Jorge .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (11) :20997-21010

[2]

Akar T K, 2012, OXIDATIVE STRESS MOL, P145

[3] Effects of estrogen-only therapy on LDL oxidation in women with hysterectomy:: Does paraoxonase genotype play a role? [J].

Akçay, YD ;

Sagin, FG ;

Sendag, F ;

Oztekin, K ;

Sozmen, EY .

MATURITAS, 2006, 53 (03) :325-332

[4] Are PON1 Q/R 192 and M/L 55 polymorphisms risk factors for diabetes complications in Turkish population? [J].

Altuner, Durdu ;

Suzen, Sinan H. ;

Ates, Ilker ;

Koc, Gonul V. ;

Aral, Yalcin ;

Karakaya, Asuman .

CLINICAL BIOCHEMISTRY, 2011, 44 (5-6) :372-376

[5] Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer [J].

Antognelli, C ;

Mearini, L ;

Talesa, VN ;

Giannantoni, A ;

Mearini, E .

PROSTATE, 2005, 63 (03) :240-251

[6] Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development [J].

Aviram, M ;

Rosenblat, M .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (09) :1304-1316

[7] Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants [J].

Aviram, M ;

Rosenblat, M ;

Billecke, S ;

Erogul, J ;

Sorenson, R ;

Bisgaier, CL ;

Newton, RS ;

La Du, B .

FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (7-8) :892-904

[8] Paraoxonase 1 mutations in a Turkish population [J].

Aynacioglu, AS ;

Cascorbi, I ;

Mrozikiewicz, PM ;

Nacak, M ;

Tapanyigit, EE ;

Roots, I .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1999, 157 (03) :174-177

[9] Serum paraoxonase 1 activity is decreased in thyroid dysfunction [J].

Azizi, F ;

Raiszadeh, F ;

Solati, M ;

Etemadi, A ;

Rahmani, M ;

Arabi, M .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2003, 26 (08) :703-709

[10] Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment [J].

Baskol, G. ;

Atmaca, H. ;

Tanriverdi, F. ;

Baskol, M. ;

Kocer, D. ;

Bayram, F. .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2007, 115 (08) :522-526

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