Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease

被引：8

作者：

Osborne-Crowley, Katherine ^{[1
,2
]}

Andrews, Sophie C. ^{[3
]}

Labuschagne, Izelle ^{[4
]}

Nair, Akshay ^{[1
,2
]}

Scahill, Rachael ^{[1
,2
]}

Craufurd, David ^{[5
,6
]}

Tabrizi, Sarah J. ^{[1
,2
]}

Stout, Julie C. ^{[3
]}

Campbell, C. ^{[7
,21
]}

Campbell, M. ^{[7
]}

Frajman, E. ^{[7
]}

Milchman, C. ^{[7
]}

O'Regan, A. ^{[7
]}

Coleman, A. ^{[8
]}

Santos, R. Dar ^{[8
]}

Decolongon, J. ^{[8
]}

Sturrock, A. ^{[8
]}

Bardinet, E. ^{[9
]}

Jauffret, C. ^{[9
]}

Justo, D. ^{[9
]}

Lehericy, S. ^{[9
]}

Marelli, C. ^{[9
]}

Nigaud, K. ^{[9
]}

Pourchot, P. ^{[9
]}

Valabregue, R. ^{[9
]}

Bechtel, N. ^{[10
]}

Bohlen, S. ^{[10
]}

Reilmann, R. ^{[10
]}

Hoffman, A. ^{[11
]}

Kraus, P. ^{[11
]}

Landwehrmeyer, B. ^{[12
]}

van den Bogaard, S. J. A. ^{[13
]}

Dumas, E. M. ^{[13
]}

van der Grond, J. ^{[13
]}

t'Hart, E. P. ^{[13
]}

Jurgens, C. ^{[13
]}

Witjes-Ane, M. -N. ^{[13
]}

Arran, N. ^{[14
]}

Callaghan, J. ^{[14
]}

Stopford, C. ^{[14
]}

Frost, C. ^{[15
]}

Jones, R. ^{[15
]}

Berna, C. ^{[16
]}

Crawford, H. ^{[16
]}

Fox, N. ^{[16
]}

Gibbard, C. ^{[16
]}

Hobbs, N. ^{[16
]}

Lahiri, N. ^{[16
]}

Malone, I. ^{[16
]}

Ordidge, R. ^{[16
]}

机构：

[1] UCL, Huntingtons Dis Ctr, Inst Neurol, London, England

[2] Natl Hosp Neurol & Neurosurg, London, England

[3] Monash Univ, Sch Psychol Sci, Monash Inst Cognit & Clin Neurosci, Melbourne, Vic, Australia

[4] Australian Catholic Univ, Cognit & Emot Res Ctr, Sch Psychol, Melbourne, Vic, Australia

[5] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Manchester Ctr Genom Med,Sch Biol Sci,Div Evolut, Manchester, Lancs, England

[6] Cent Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[7] Monash Univ, Clayton, Vic, Australia

[8] Univ British Columbia, Vancouver, BC, Canada

[9] Hop La Pitie Salpetriere, AP HP, Paris, France

[10] Univ Munster, Munster, Germany

[11] Univ Bochum, Bochum, Germany

[12] Univ Ulm, Ulm, Germany

[13] Leiden Univ, Med Ctr, Leiden, Netherlands

[14] St Marys Hosp, Manchester, Lancs, England

[15] London Sch Hyg & Trop Med, London, England

[16] UCL, London, England

[17] Imperial Coll London, London, England

[18] IXICO, London, England

[19] Univ Iowa, Iowa City, IA USA

[20] Harvard, Massachusetts Gen Hosp, Boston, MA USA

[21] Indiana Univ, Bloomington, IN 47405 USA

[22] CHDI, Los Angeles, CA USA

来源：

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | 2019年 / 25卷 / 05期

基金：

英国惠康基金;

关键词：

Huntington's disease; Emotion; Apathy; Social behavior; Cognition; Cognition disorders; EMOTION RECOGNITION; BEHAVIORAL-CHANGES; SOCIAL COGNITION; NEURAL SYSTEMS; BASAL GANGLIA; DEFICITS; PATIENT; SYMPTOMS; CORTEX; HD;

D O I：

10.1017/S1355617718001224

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: Previous research has demonstrated an association between emotion recognition and apathy in several neurological conditions involving fronto-striatal pathology, including Parkinson's disease and brain injury. In line with these findings, we aimed to determine whether apathetic participants with early Huntington's disease (HD) were more impaired on an emotion recognition task compared to non-apathetic participants and healthy controls. Methods: We included 43 participants from the TRACK-HD study who reported apathy on the Problem Behaviours Assessment - short version (PBA-S), 67 participants who reported no apathy, and 107 controls matched for age, sex, and level of education. During their baseline TRACK-HD visit, participants completed a battery of cognitive and psychological tests including an emotion recognition task, the Hospital Depression and Anxiety Scale (HADS) and were assessed on the PBA-S. Results: Compared to the non-apathetic group and the control group, the apathetic group were impaired on the recognition of happy facial expressions, after controlling for depression symptomology on the HADS and general disease progression (Unified Huntington's Disease Rating Scale total motor score). This was despite no difference between the apathetic and non-apathetic group on overall cognitive functioning assessed by a cognitive composite score. Conclusions: Impairment of the recognition of happy expressions may be part of the clinical picture of apathy in HD. While shared reliance on frontostriatal pathways may broadly explain associations between emotion recognition and apathy found across several patient groups, further work is needed to determine what relationships exist between recognition of specific emotions, distinct subtypes of apathy and underlying neuropathology. (JINS, 2019, 25, 453-461)

引用

页码：453 / 461

页数：9

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