In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?

被引：59

作者：

Havenaar, Robert ^{[1
]}

Anneveld, Bart ^{[1
]}

Hanff, Lidwien M. ^{[2
,3
]}

de Wildt, Saskia N. ^{[2
,3
]}

de Koning, Barbara A. E. ^{[2
,3
]}

Mooij, Miriam G. ^{[2
,3
]}

Lelieveld, Jan P. A. ^{[1
]}

Minekus, Mans ^{[1
]}

机构：

[1] TNO, NL-3700 AJ Zeist, Netherlands

[2] Erasmus MC, Sophia Childrens Hosp, Dept Clin Pharm, NL-3000 CB Rotterdam, Netherlands

[3] Dept Pediat Surg & Intens Care, NL-3000 CB Rotterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 457卷 / 01期

关键词：

Pediatric drug; Drug handling; Bioaccessibility; In vitro gastrointestinal model; DRUG-DELIVERY; PHARMACOKINETICS; ABSORPTION; SYSTEM; FORMULATIONS; PARACETAMOL; INTESTINE; STATES;

D O I：

10.1016/j.ijpharm.2013.07.053

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the conditions in the upper gastrointestinal tract of neonates, infants and toddlers: TIMpediatric. Paracetamol and diclofenac in age-related food matrices and with esomeprazole co-medication were tested. The experiments showed relevant results on the impact of drug manipulation and co-medication on the availability for absorption of active compounds. Without ethical constraints, alternative approaches for oral dosing and new pediatric formulations can be studied in TIMpediatric with a high predictive value. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：327 / 332

页数：6

共 32 条

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