Efficiency of bortezomib, melfalane, and prednisolone combination in patients with multiple myeloma

被引：0

作者：

Luchinin, A. S. ^{[1
]}

Zagoskina, T. P. ^{[1
]}

机构：

[1] Inst Hematol & Blood Transfus, Kirov, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2009年 / 54卷 / 04期

关键词：

multiple myeloma; chemotherapy; bortezomib; melfalane; prednisolone; complete remission; STAGING SYSTEM; MELPHALAN;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Efficiency of bortezomib, melfalane, and prednisolone combination in patients with multiple myeloma. Luchinin A. S., Zagoskina T. P. Institute of Hematology and Blood Transfusion, Kirov. Bortezomib is a proteosome inhibitor. Monotherapy with Bortezomib is effective in patients with resistant and relapsing multiple myeloma (MM). We analyzed the efficiency of the combination treatment with bortezomib, melfalane and prednisolone (VMP) in patients with MM. 27 patients were included in the study: 18 patients with refractory form of MM and 9 patients with de novo MM. Mean age of the patients was 60 years (45-77). Total response to therapy was 93%. Complete remission was achieved in 48%, partial remission in 26% patients. The most frequent side effects of VMP therapy were neutropenia (57.7%), thrombocytopenia (65.4%), peripheral neuropathy (65.4%), asthenia (61.5%), and infection complications (61.5%).

引用

页码：9 / 13

页数：5

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