Dimemorfan enhances acetylcholine release from rat hippocampal slices

被引：4
作者：
Wang, HH
Chou, YC
Liao, JF
Chen, CF
机构：
[1] Natl Yang Ming Univ, Dept Pharmacol, Taipei 112, Taiwan
[2] Vet Gen Hosp, Dept Pharm, Taipei, Taiwan
[3] Natl Res Inst Chinese Med, Taipei, Taiwan
[4] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan
来源：
BRAIN RESEARCH | 2004年 / 1008卷 / 01期
关键词：
dimemorfan; sigma(1) receptor; acetylcholine release; hippocampal slice; striatal slice;
D O I：
10.1016/j.brainres.2004.02.014
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Our previous study reported that an antitussive drug, dimemorfan, attenuates cholinergic dysfunction-induced amnesia in mice and acts like a sigma(1) receptor agonist. This study further showed that dimemorfan (30 muM), like the putative sigma(1) receptor agonist (+)-SKF-10047 (10 muM), significantly enhanced 25 mM KCI-evoked [H-3]acetylcholine release from rat hippocampal but not striatal slices, which was antagonized by a sigma(1) receptor antagonist haloperidol (0.3 muM). (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：113 / 115
页数：3
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