Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-Reactive Protein, Interleukin 6 and Tumor Necrosis Factor α: A Meta-Analysis

被引：196
作者：
Li, Kelei [1 ,2 ]
Huang, Tao [1 ,2 ]
Zheng, Jusheng [1 ,2 ]
Wu, Kejian [1 ,2 ]
Li, Duo [1 ,2 ]
机构：
[1] Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou 310003, Zhejiang, Peoples R China
[2] APCNS Ctr Nutr & Food Safety, Hangzhou, Zhejiang, Peoples R China
来源：
PLOS ONE | 2014年 / 9卷 / 02期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
FISH-OIL SUPPLEMENTATION; CARDIOVASCULAR RISK-FACTORS; HUMAN ADIPOSE-TISSUE; NF-KAPPA-B; INFLAMMATORY MARKERS; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; OXIDATIVE STRESS; WEIGHT-LOSS; OMEGA-3-FATTY-ACID SUPPLEMENTATION;
D O I：
10.1371/journal.pone.0088103
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Previous studies did not draw a consistent conclusion about the effects of marine-derived n-3 polyunsaturated fatty acids (PUFAs) on fasting blood level of C-reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Methods and Findings: A comprehensive search of Web of Science, PubMed, Embase and Medline (from 1950 to 2013) and bibliographies of relevant articles was undertaken. Sixty-eight RCTs with a total of 4601 subjects were included in the meta-analysis. Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). A significant negative linear relationship between duration and effect size of marine-derived n-3 PUFAs supplementation on fasting blood levels of TNF-alpha and IL-6 in subjects with chronic non-autoimmune disease was observed, indicating that longer duration of supplementation could lead to a greater lowering effect. A similar linear relationship was also observed for IL-6 levels in healthy subjects. Restricted cubic spline analysis and subgroup analysis showed that the lowering effect of marine-derived n-3 PUFAs on CRP, IL-6 and TNF-alpha in subjects with chronic non-autoimmune disease became weakened when body mass index was greater than 30 kg/m(2). The effect of marine-derived n-3 PUFAs from dietary intake was only assessed in subjects with chronic non-autoimmune disease, and a significant lowering effect was observed on IL-6, but not on CRP and TNF-alpha. Conclusions: Marine-derived n-3 PUFAs supplementation had a significant lowering effect on CRP, IL-6 and TNF-alpha level. The lowering effect was most effective in non-obese subjects and consecutive long-term supplementation was recommended.
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页数：28
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