Protective Effect of Pistacia lentiscus Oil Against Bleomycin-Induced Lung Fibrosis and Oxidative Stress in Rat

被引:27
作者
Abidi, Anouar [1 ]
Aissani, Nadhem [2 ]
Sebai, Hichem [2 ]
Serairi, Raja [3 ]
Kourda, Nadia [4 ]
Ben Khamsa, Saloua [1 ]
机构
[1] Fac Med Tunis, Unit Res 03 UR 08 05, Pulm Fibrosis Prevent & Treatment, Tunis, Tunisia
[2] Univ Jendouba, High Inst Biotechnol Beja, Lab Funct Physiol & Valorizat Bioresource, Ave Habib Bourguiba, Beja 3829000, Tunisia
[3] Nat Sch Hlth Sci Tunis, Tunis, Tunisia
[4] Charles Nicolle Hosp, Dept Anat & Pathol, Tunis, Tunisia
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2017年 / 69卷 / 03期
关键词
GROWTH-FACTOR-BETA; EXPERIMENTAL PULMONARY-FIBROSIS; POLYUNSATURATED FATTY-ACIDS; ANTIINFLAMMATORY ACTIVITY; PHENOLIC-COMPOUNDS; IN-VITRO; EXTRACT; SEED; KIDNEY; MODEL;
D O I
10.1080/01635581.2017.1283423
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We aimed in the present study to investigate the protective effect of Pistacia lentiscus oil against bleomycin-induced lung fibrosis as well as the involvement of oxidative stress in such protection. In this respect, adult male Wistar rats were used and divided into three groups of twenty each: control (NaCl, 0.9%), bleomycin, and bleomycin (4 mg/kg b.w.) + P. lentiscus oil (3 g/kg, b.w.). Animals were pretreated for 30 days before the induction of fibrosis by bleomycin and 1 wk after the induction of fibrosis. The oil principal compounds detected by gas chromatography analysis are: Linoleic and palmitic acids (70.6 and 24.7%, respectively). Our data demonstrated that P. lentiscus oil protected against bleomycin-induced fibrosis as evidenced by TGF beta immunostaining increase in lungs fibrocytes as well as inflammatory infiltrate. We also showed that acute bleomycin-induced fibrosis was accompanied by an oxidative stress in lung tissue as assessed by an increase of lipid peroxidation as well as antioxidant enzyme activities depletion such as superoxide dismutase (SOD) and catalase (CAT). More importantly, P. lentiscus oil treatment reversed all bleomycin-induced oxidative stress parameters disturbances. In conclusion, we suggest that P. lentiscus oil had potent protective effects against bleomycin-induced fibrosis due in part to its antioxidant properties. [GRAPHICS] .
引用
收藏
页码:490 / 497
页数:8
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