Regulation of CD47 expression in cancer cells

被引：74
作者：
Huang, Can-Yu [1 ]
Ye, Zi-Han [1 ]
Huang, Mu-Yang [1 ]
Lu, Jin-Jian [1 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, 5005a,N22,Ave Univ, Taipa, Macao, Peoples R China
来源：
TRANSLATIONAL ONCOLOGY | 2020年 / 13卷 / 12期
关键词：
CD47; Cytokine; Oncogene; MicroRNA; QPCTL; INTEGRIN-ASSOCIATED PROTEIN; HUMAN GLUTAMINYL CYCLASE; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; TUMOR-SUPPRESSOR; B7-H1; EXPRESSION; TARGETING CD47; UP-REGULATION; STEM-CELLS; SIRP-ALPHA;
D O I：
10.1016/j.tranon.2020.100862
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CD47 is overexpressed in various types of cancers and it can directly bind with SIRP alpha, which is mainly located on macrophages. The binding of CD47-SIRP alpha transmits a "don't eat me" signal, which can prevent cancer cells from immune clearance. Targeting the phagocytosis checkpoint of CD47-SIRP alpha axis has shown remarkable anticancer effect in preclinical and clinical research, which indicates the potential application of CD47-SIRP alpha blockade for cancer treatment. In this case, the comprehensive description of the regulation of CD47 in different types of cancer cells has significant implications for furthering our understanding of the role of CD47 in cancer. Based on the current reports, we summarized the regulatory factors, i.e., cytokines, oncogenes, microRNAs as well as enzymes, of CD47 expression in cancer cells. Accordingly, we also proposed several points needing further research, hoping to provide useful insights for the future investigation on the regulation of CD47 in cancers.
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页数：7
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