Hybrid Mesoporous Silica-Based Drug Carrier Nanostructures with Improved Degradability by Hydroxyapatite

被引：208

作者：

Hao, Xiaohong ^{[1
]}

Hu, Xixue ^{[2
]}

Zhang, Cuimiao ^{[1
]}

Chen, Shizhu ^{[1
]}

Li, Zhenhua ^{[1
]}

Yang, Xinjian ^{[1
]}

Liu, Huifang ^{[1
]}

Jia, Guang ^{[1
]}

Liu, Dandan ^{[1
]}

Ge, Kun ^{[1
]}

Liang, Xing-Jie ^{[2
]}

Zhang, Jinchao ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

来源：

ACS NANO | 2015年 / 9卷 / 10期

基金：

高等学校博士学科点专项科研基金; 中国博士后科学基金;

关键词：

silica/hydroxyapatite hybrid nanoparticles; biodegradability; pH sensitivity; anticancer drug carrier; IN-VIVO; CONTROLLED-RELEASE; HEMOLYTIC-ACTIVITY; CANCER-THERAPY; DELIVERY-SYSTEM; NANOPARTICLES; BIODISTRIBUTION; LUMINESCENT; PH; BIOCOMPATIBILITY;

D O I：

10.1021/nn507485j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Potential bioaccumulation is one of the biggest limitations for silica nanodrug delivery systems in cancer therapy. In this study, a mesoporous silica nanoparticles/hydroxyapatite (MSNs/HAP) hybrid drug carrier, which enhanced the biodegradability of silica, was developed by a one-step method. The morphology and structure of the nanoparticles were characterized by TEM, DLS, FT-IR, XRD, N-2 adsorption desorption isotherms, and XPS, and the drug loading and release behaviors were tested. TEM and ICP-OES results indicate that the degradability of the nanoparticles has been significantly improved by Ca2+ escape from the skeleton in an acid environment. The MSNs/HAP sample exhibits a higher drug loading content of about 5 times that of MSNs. The biological experiment results show that the MSNs/HAP not only exhibits good bioconnpatibility and antitumor effect but also greatly reduces the side effects of free DOX. The as-synthesized hybrid nanoparticles may act as a promising drug delivery system due to their good biocompatibility, high drug loading efficiency, pH sensitivity, and excellent biodegradability.

引用

页码：9614 / 9625

页数：12

共 47 条

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