Specificity and degeneracy: T cell recognition in CNS autoimmunity

被引：6
作者：
Zhou, D [1 ]
Hemmer, B [1 ]
机构：
[1] Univ Marburg, Dept Neurol, Clin Neuroimmunol Grp, D-35033 Marburg, Germany
来源：
MOLECULAR IMMUNOLOGY | 2004年 / 40卷 / 14-15期
关键词：
degeneracy; T cell recognition; autoimmunity; multiple sclerosis; Lyme disease;
D O I：
10.1016/j.molimm.2003.11.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T cells play a crucial role in the pathogenesis of most autoimmune disorders. However, target antigens and pathomechanisms leading to human autoimmune diseases are still largely unknown. Cross-recognition of T cells between self and foreign antigens has been considered as a driving force in generating autoimmunity. Here, we discuss the extent of degeneracy in T cell antigen recognition and hypothesize on the role of degenerate recognition in the pathogenesis of multiple sclerosis (MS), a candidate autoimmune disease of the central nervous system (CNS). (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1057 / 1061
页数：5
相关论文
共 40 条
  • [1] Archelos JJ, 2000, ANN NEUROL, V47, P694, DOI 10.1002/1531-8249(200006)47:6<694::AID-ANA2>3.3.CO
  • [2] 2-N
  • [3] Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    Babbe, H
    Roers, A
    Waisman, A
    Lassmann, H
    Goebels, N
    Hohlfeld, R
    Friese, M
    Schröder, R
    Deckert, M
    Schmidt, S
    Ravid, R
    Rajewsky, K
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (03) : 393 - 404
  • [4] Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
    Benoist, C
    Mathis, D
    [J]. NATURE IMMUNOLOGY, 2001, 2 (09) : 797 - 801
  • [5] Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    Bielekova, B
    Goodwin, B
    Richert, N
    Cortese, I
    Kondo, T
    Afshar, G
    Gran, B
    Eaton, J
    Antel, J
    Frank, JA
    McFarland, HF
    Martin, R
    [J]. NATURE MEDICINE, 2000, 6 (10) : 1167 - 1175
  • [6] B cells and antibodies in CNS demyelinating disease
    Cross, AH
    Trotter, JL
    Lyons, JA
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2001, 112 (1-2) : 1 - 14
  • [7] Structural basis of T cell recognition
    Garcia, KC
    Teyton, L
    Wilson, LA
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 369 - +
  • [8] The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis - Identification and characterization of the primary demyelinating lesion
    Gay, FW
    Drye, TJ
    Dick, GWA
    Esiri, MM
    [J]. BRAIN, 1997, 120 : 1461 - 1483
  • [9] Identification of autoantibodies associated with myelin damage in multiple sclerosis
    Genain, CP
    Cannella, B
    Hauser, SL
    Raine, CS
    [J]. NATURE MEDICINE, 1999, 5 (02) : 170 - 175
  • [10] The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
    Germain, RN
    Stefanova, I
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 467 - 522
1234