Isocoumarins from American cockroach (Periplaneta americana) and their cytotoxic activities

被引：42

作者：

Luo, Shi-Lin ^{[1
,2
,3
]}

Huang, Xiao-Jun ^{[2
,3
]}

Wang, Ying ^{[2
,3
]}

Jiang, Ren-Wang ^{[2
]}

Wang, Lei ^{[2
,3
]}

Bai, Liang-Liang ^{[2
]}

Peng, Qun-Long ^{[2
]}

Song, Cai-Lu ^{[2
,3
]}

Zhang, Dong-Mei ^{[2
]}

Ye, Wen-Cai ^{[1
,2
,3
]}

机构：

[1] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Jiangsu, Peoples R China

[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Coll Pharm, JNU HKUST Joint Lab Neurosci & Innovat Drug Res, Guangzhou 510632, Guangdong, Peoples R China

来源：

FITOTERAPIA | 2014年 / 95卷

基金：

中国国家自然科学基金;

关键词：

American cockroach; Periplaneta americana; Isocoumarin; Cytotoxicity; STRUCTURAL ELUCIDATION; RETROCEREBRAL COMPLEX; EXPRESSION; INSECT;

D O I：

10.1016/j.fitote.2014.03.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new isocoumarins (1-4), along with three known ones (5-7), were isolated from the 70% ethanol extract of the whole body of the traditional Chinese insect medicine, American cockroach (Periplaneta americana). The structures with absolute configurations of new compounds were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment and CD analyses. Compounds 3-5 showed significant cytotoxic activities in HepG2 and MCF-7 cells with IC50 values in the ranges 6.41-23.91 mu M and 6.67-39.07 mu W, respectively. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：115 / 120

页数：6

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