A structural view of microtubule dynamics

被引：77

作者：

Nogales, E ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 56卷 / 1-2期

关键词：

tubulin; microtubule; dynamic instability; nucleotide; structure; electron crystallography;

D O I：

10.1007/s000180050012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The essential microtubule property of dynamic instability is based on the binding, hydrolysis and exchange of GTP in each tubulin dimer. The recent high-resolution structures of tubulin and the microtubule have given us the first view at atomic level of properties such as nucleotide exchangeability, the linkage between polymerization and nucleotide hydrolysis, and the origin of microtubule destabilization, as well as the mode of action of antimitotic agents such as taxol.

引用

页码：133 / 142

页数：10

共 41 条

[1] 3-DIMENSIONAL STRUCTURE OF TUBULIN PROTOFILAMENTS [J].

AMOS, LA ;

BAKER, TS .

NATURE, 1979, 279 (5714) :607-612

[2] How Taxol® stabilises microtubule structure [J].

Amos, LA ;

Löwe, J .

CHEMISTRY & BIOLOGY, 1999, 6 (03) :R65-R69

[3] LOW RESOLUTION STRUCTURE OF MICROTUBULES IN SOLUTION - SYNCHROTRON X-RAY-SCATTERING AND ELECTRON-MICROSCOPY OF TAXOL-INDUCED MICROTUBULES ASSEMBLED FROM PURIFIED TUBULIN IN COMPARISON WITH GLYCEROL AND MAP-INDUCED MICROTUBULES [J].

ANDREU, JM ;

BORDAS, J ;

DIAZ, JF ;

DEANCOS, JG ;

GIL, R ;

MEDRANO, FJ ;

NOGALES, E ;

PANTOS, E ;

TOWNSANDREWS, E .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 226 (01) :169-184

[4] Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules [J].

Belmont, LD ;

Mitchison, TJ .

CELL, 1996, 84 (04) :623-631

[5]

BURNS RG, 1993, MICROTUBULES, P3

[6] REGULATION OF MICROTUBULE DYNAMIC INSTABILITY [J].

CASSIMERIS, L .

CELL MOTILITY AND THE CYTOSKELETON, 1993, 26 (04) :275-281

[7] STRUCTURE OF GROWING MICROTUBULE ENDS - 2-DIMENSIONAL SHEETS CLOSE INTO TUBES AT VARIABLE RATES [J].

CHRETIEN, D ;

FULLER, SD ;

KARSENTI, E .

JOURNAL OF CELL BIOLOGY, 1995, 129 (05) :1311-1328

[8]

DAI K, 1994, J BACTERIOL, V175, P130

[9] THE ESSENTIAL BACTERIAL CELL-DIVISION PROTEIN FTSZ IS A GTPASE [J].

DEBOER, P ;

CROSSLEY, R ;

ROTHFIELD, L .

NATURE, 1992, 359 (6392) :254-256

[10] Microtubule polymerization dynamics [J].

Desai, A ;

Mitchison, TJ .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :83-117

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