Mouse models of cancer-associated thrombosis

被引：30

作者：

Hisada, Yohei ^{[1
,2
]}

Mackman, Nigel ^{[1
,3
]}

机构：

[1] Univ North Carolina Chapel Hill, Thrombosis & Hemostasis Program, Div Hematol & Oncol, Dept Med, Chapel Hill, NC 27599 USA

[2] Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway

[3] Univ North Carolina Chapel Hill, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA

来源：

THROMBOSIS RESEARCH | 2018年 / 164卷

关键词：

Cancer; Mouse model; Neutrophil extracellular traps; Tissue factor; Venous thrombosis; DEEP-VEIN THROMBOSIS; TISSUE FACTOR EXPRESSION; EXTRACELLULAR DNA TRAPS; HUMAN LUNG-CARCINOMA; VENOUS THROMBOSIS; PANCREATIC-CANCER; IN-VIVO; XENOGRAFT MODEL; COAGULATION ACTIVATION; TUMOR XENOGRAFTS;

D O I：

10.1016/j.thromres.2017.12.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cancer patients have an increased risk of venous thromboembolism (VTE) compared with the general population. Mouse models are used to better understand the mechanisms of cancer-associated thrombosis. Several mouse models of cancer-associated thrombosis have been developed that use different mouse strains, tumors, tumor sites and thrombosis models. In this review, we summarize these different models. These models have been used to determine the role of different pathways in cancer-associated thrombosis. For instance, they have revealed roles for tumor-derived tissue factor-positive microvesicles and neutrophil extracellular traps in thrombosis in tumor-bearing mice. A better understanding of the mechanisms of cancer-associated thrombosis may allow the development of new therapies to reduce thrombosis in cancer patients.

引用

页码：S48 / S53

页数：6

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